2580
Anal. Chem. 1982, 5 4 , 2560-2566
the adsorption process in such that, a t least with urine samples, no sample treatment is required. As a result, total analysis times of less than 10 min are obtained and no additional instrumentation is required beyond the conventional differential pulse polarograph. Further optimization of this analysis method for adriamycin-derived compounds and its more extensive application in the characterization of clinical samples is continuing in our laboratory.
ACKNOWLEDGMENT We thank T. M. Woodcock and K. A. Lalley both for their invaluable suggestions concerning this work and for providing the adriamycin samples used herein.
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RECEIVED for review July 26, 1982. Accepted September 20, 1982. This research was supported by the National Science Foundation RIAS Grant No. 77-06911 and by the University of Louisville College of Arts and Sciences. The work was presented in part at the 33rd Annual Southeastern Meeting of the American Chemical Society, Lexington, KY, Nov 1981.
Fiber Optic Thin-Layer Spectroelectrochemistry with Long Optical Path Jeffrey D. Brewster and James L. Anderson* Department of Chemistry, University of Georgia, Athens, Georgla 30602
A novel approach has been developed for the spectroelectrochemlcal characterlzatlon of very small volumes of very weak chromophores Including redox enzymes. The approach uses fiber optics to couple a thin-layer spectroelectrochemlcal cell (volume
