Finnigan LC/MS permits rapid determination of LSD and other thermally-labile compounds. Finnigan's ingenious LC/MS Interface makes it possible to bring the pre cision of mass spectrom etry to the quantitative and qualitative analysis of many difficult samples, including such thermally fragile substances as LSD and psilocybin. The Interface uti lizes a continuous moving belt to carry the LC eluent through a series of vacuum locks and di rectly into the ion source of the mass spectrometer. This combination of liq uid chromatography and mass spectroscopy allows the identification and quantitation (nanogram level) of thermally labile compounds using sophis
ticated techniques like Pulsed Positive-Ion Nega tive-Ion Chemical Ioniza tion (PPINICI) and Multiple Ion Detection. Samples such as non-volatile liquids
and suspended solids can be introduced by direct application to the belt, utilizing the inter face as a high-speed automated solid probe.
ORANGE SUNSHINE BY LC/MS POSITIVE ION CI-AMMONIA
In a paper pre sented at the March Pittsburgh Conference, authors Paul E. Kelly and Ronald F. Skinner discuss in detail h o w standards and samples were prepared and analyzed by HPLC/MS. Copies of the paper, " A Rapid Method for the Determination of Selected Hallucinogenic Drugs Via Positive/Nega tive Ion LC/MS"and details of other applications are available on request.
finnigan Contrast the indeterminate signal from U.V excitation of the HPLC eluent w i t h the distinctive " t h u m b p r i n t " of LSD delivered by the Finnigan 4 0 0 0 utilizing the LC/MS Interface. CIRCLE 7 5
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