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Bioactive Constituents, Metabolites, and Functions
Fish oil supplementation alleviates the altered lipid homeostasis in blood, liver and adipose tissues in high-fat diet-fed rats Chen-Yuan Chiu, Lou-Pin Wang, Shing-Hwa Liu, and Meng Tsan Chiang J. Agric. Food Chem., Just Accepted Manuscript • DOI: 10.1021/acs.jafc.8b00529 • Publication Date (Web): 07 Apr 2018 Downloaded from http://pubs.acs.org on April 9, 2018
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Journal of Agricultural and Food Chemistry
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Original article
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Fish oil supplementation alleviates the altered lipid homeostasis in
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blood, liver and adipose tissues in high-fat diet-fed rats
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Chen-Yuan Chiua, Lou-Pin Wangb, Shing-Hwa Liuc,d,e,*, Meng-Tsan Chiangb,*
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a
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Taipei 100, Taiwan
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b
Institute of Food Safety and Health, College of Public Health, National Taiwan University,
Department of Food Science, College of Life Science, National Taiwan Ocean University,
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Keelung 202, Taiwan
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c
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100, Taiwan
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d
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Taipei 100, Taiwan
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e
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University, Taichung 404, Taiwan
Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei
Department of Pediatrics, College of Medicine and Hospital, National Taiwan University,
Department of Medical Research, China Medical University Hospital, China Medical
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*Correspondence: Shing-Hwa Liu, Ph.D., Institute of Toxicology, College of Medicine,
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National Taiwan University, Taipei, 10051, Taiwan. Telephone: 886-2-23123456, ext. 88605;
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Fax: 886-2-23410217; E-mail:
[email protected]; or Meng-Tsan Chiang, Ph.D.,
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Department of Food Science, College of Life Science, National Taiwan Ocean University,
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Keelung 202, Taiwan. Telephone: +886-2-24622192, ext. 5117/5118. Fax: +886-2-24634203;
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E-mail:
[email protected].
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ACS Paragon Plus Environment
Journal of Agricultural and Food Chemistry
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Abstract
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This study investigated the effects of dietary supplementation of fish oil on the signals of
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lipid metabolism involved in hepatic cholesterol and triglyceride influx and excretion in
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high-fat diet (HFD)-fed rats. Fish oil (FO) repressed body (HFD: 533±18.2 g, HFD+FO:
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488±28.0 g, p
