Letter pubs.acs.org/OrgLett
Flow Chemistry on Multigram Scale: Continuous Synthesis of Boronic Acids within 1 s Andreas Hafner, Mark Meisenbach, and Joerg Sedelmeier* Novartis Campus, Novartis Pharma AG, 4002 Basel, Switzerland S Supporting Information *
ABSTRACT: The benefits and limitations of a simple continuous flow setup for handling and performing of organolithium chemistry on the multigram scale is described. The developed metalation platform embodies a valuable complement to existing methodologies, as it combines the benefits of Flash Chemistry (chemical synthesis on a time scale of
