Editorial pubs.acs.org/OPRD
Fluorine Chemistry Special Feature
W
e are happy to introduce this special edition on organofluorine chemistry for Organic Process Research & Development (OPRD). The incorporation of fluorine or fluorinated moieties into organic compounds plays a key role in life-science oriented research as often profound changes of the physicochemical and biological properties can be observed. As a consequence, organofluorine chemistry has become an integral part of pharmaceutical and agrochemical research. About 20% of all modern pharmaceuticals and roughly 40% of modern agrochemicals are fluorinated molecules. During the last few decades, new techniques have been developed to introduce fluorinated substituents onto aryl and heterocyclic rings, motifs that are highly interesting for the pharmaceutical and agrochemical industries to modulate the performance and pharmacokinetics of active ingredients. However, a huge demand still remains for new innovative solutions for the introduction of fluorine into organic substrates. The steady increase in human population drives an ever-increasing need to improve health care and agronomic performance; this, together with an ever-increasing desire from society for high-performance organic materials and polymers with unique properties, continues to drive fluorine chemistry and the need to develop new synthetic methods and new building blocks to access new classes of compounds. Further development of these chemistries into environmentally benign production processes will be an ever more frequent challenge. This special issue covers several areas of innovative research in the field of fluorine chemistry with particular emphasis, as appropriate for this journal, related to processes which are capable of further industrial scale-up. We thank all of the authors who have contributed to this special edition.
Frederic Leroux CNRS-Université de Strasbourg, UMR 7509, SynCat, 25 Rue Becquerel, 67087 Strasbourg Cedex 02, France
Mark Ford* Bayer CropScience AG, Industriepark Höchst G836, 65926 Frankfurt am Main, Germany
Sergiy Pazenok*
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Bayer CropScience AG, Alfred-Nobel Straße 50, 40789 Monheim, Germany
AUTHOR INFORMATION
Corresponding Authors
*E-mail:
[email protected]. *E-mail:
[email protected]. Notes
Views expressed in this editorial are those of the author and not necessarily the views of the ACS.
Special Issue: Fluorine Chemistry 14 Published: July 29, 2014 © 2014 American Chemical Society
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dx.doi.org/10.1021/op500216s | Org. Process Res. Dev. 2014, 18, 980−980
