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Cite This: ACS Appl. Mater. Interfaces 2019, 11, 13833−13834
Forum on Translational DNA Nanotechnology
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ince the initial work of Nadrian C. Seeman in the 1980s,1 DNA has been increasingly utilized as a type of biomaterial to construct self-assembled nanostructures. DNA hybridization following the highly specific Watson−Crick base-pairing rule has been exploited to design static and dynamic DNA/RNA nanostructures for a multitude of purposes. With the rapid expansion of the field, there has been ever-increasing demand for translational applications of these precisely assembled nucleic acids nanostructures. This issue of ACS Applied Materials& Interfaces features a Forum on Translational DNA Nanotechnology, which is based on selected contributions that were presented at the Sixth International Workshop on DNA Nanotechnology, held August 26−28, 2017, in Beijing, China. This symposium was organized by Dongsheng Liu (Tsinghua University, China), Jwa-Min Nam (Seoul National University, Korea), Chunhai Fan (Shanghai Institute of Applied Physics, CAS, China), and Shu Wang (Institute of Chemistry, CAS, China). The forum highlights the state-of-the-art advancement in the field of DNA nanotechnology, focusing on the translational applications of self-assembled DNA nanostructures. It contains six research articles and two reviews authored by several leading research groups in the field, providing readers selected examples on translational DNA nanotechnology. In the current issue, recent advances in DNA-templated fabrication of novel nanocomposites are presented in one research article and two reviews. Chengde Mao’s group, from Purdue University, reports a nanopatterning strategy using DNA origami as structural templates. Relying on nonspecific charge−charge interactions, various nanoparticles, including DNA motifs, gold nanoparticles, proteins, and silica complex, can be patterned into large 2D arrays (>4 × 4 μm). Baoquan Ding’s group summarizes in a review the recent efforts on metal nanoarchitecture fabrication at the National Center for NanoScience and Technology in Beijing, China, taking merit of spatial addressability of DNA nanostructures, focusing on DNA-assisted metal nanoparticle (NP) synthesis and particularly the use of DNA-linked NPs as building blocks for selfassembly of multifunctional NP nanocomponents, supplemented with prospects and challenges, as well as the future directions in this field. Quan Yuan’s group, from Wuhan University, addresses the recent progress of DNA nanotechnology in biomimetic applications, highlighting important examples of DNA-based artificial membrane proteins, artificial organelles, and artificial cells. Spatial control of proteins with DNA templates is described in two articles, presenting the ability of using DNA nanostructures to control biochemical fluxes. Hao Yan and co-workers, from Arizona State University, successfully engineered the redox potential of cytochrome c via DNA encapsulation with as much as ∼300 mV positive shift. By using a designed 3D DNA nanostructure attached to a gold electrode, they spatially control the orientation of cytochrome c within a tetrahedral framework and the proximal distance between cytochrome c and electrode. At Shanghai Jiao Tong © 2019 American Chemical Society
University, Chunhai Fan and co-workers report a methodology for organizing enzymes spatially onto gold electrodes using a DNA-nanostructured monolayer platform. The programmable redox enzymatic cascade pathway led to predictable generation of electrochemical signals. Advances in biomedical applications of DNA nanotechnology are also included in this forum with three research articles that pave the way to applying DNA-coated nanoparticles in clinical applications. Chung Hang Jonathan Choi and colleagues, from The Chinese University of Hong Kong, demonstrated that DNA coating is an effective strategy of promoting systemic delivery of superparamagnetic iron oxide nanoparticles (SPIONS) to atherosclerotic plaques in mice at cellular, tissue and organ level. At the University of Southampton, Antonios Kanaras and co-workers demonstrated the possibilities of targeted detection of mRNA using DNAcoated gold nanoparticles (AuNPs) in the freshwater live Hydra Vulgaris in real time by fluorescence microscopy. The Hanadi Sleiman group, at McGill University, shows delivery of nucleic acid therapeutics in a precise, stimulus-responsive manner, based on a simple and cost-effective three DNA strand design. The cargo release requires two different oligonucleotide triggers, thereby increasing the specificity of delivering therapeutics and leading to conditional gene silencing in live cells. We sincerely thank all the authors, reviewers, and editorial assistants who helped to realize this special issue. We hope this collection of articles will provide readers an overview of the status of translational DNA nanotechnology.
Nadrian C. Seeman, Margaret and Herman Sokol Professor of Chemistry New York University
Chunhai Fan, Associate Editor of ACS Applied Materials & Interfaces Shu Wang, Deputy Editor of ACS Applied Bio Materials Kirk Schanze, Editor-in-Chief of ACS Applied Materials & Interfaces Laura Fernandez, Managing Editor of ACS Applied Materials & Interfaces
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AUTHOR INFORMATION
ORCID
Nadrian C. Seeman: 0000-0002-9680-4649 Chunhai Fan: 0000-0002-7171-7338 Shu Wang: 0000-0001-8781-2535 Kirk Schanze: 0000-0003-3342-4080 Laura Fernandez: 0000-0001-7927-2233 Special Issue: Translational DNA Nanotechnology Published: April 17, 2019 13833
DOI: 10.1021/acsami.9b04482 ACS Appl. Mater. Interfaces 2019, 11, 13833−13834
ACS Applied Materials & Interfaces
Editorial
Notes
Views expressed in this editorial are those of the authors and not necessarily the views of the ACS.
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REFERENCES
(1) Seeman, N. C. Nucleic Acid Junctions and Lattices. J. Theor. Biol. 1982, 99, 237−247.
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DOI: 10.1021/acsami.9b04482 ACS Appl. Mater. Interfaces 2019, 11, 13833−13834
