Functionally substituted platinacyclobutanes. Conformation of cyclo

Synthesis of Platinacyclobutanes Bearing Biological Components for Targeted, Cisplatin Prodrugs. Bridget L. Stocker and John O. Hoberg. Organometallic...
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Volume 2 , Number 1 1 , November 1983

0 Copyright 1983 American Chemical Society

Functionally Substituted Platinacyclobutanes. Conformation of PtCI2(CH2C(CH3)(CH2OH)CH2)(C,H,N),and Related Complexes in Solution and in the Solid State J. Thomas Burton and Richard J. Puddephatt' Department of Chemistry, The University of Western Ontario, London, Ontario, Canada N6A 587

Nancy L. Jones and James A. Ibers" Department of Chemistry, Northwestern University, Evanston, Illinois, 6020 1 Received April 29, 1983

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The platinacyclobutane complexes PtC12(CH2CR'R2CH2)(C5H,N)2(R' = H, R2 = CH20H;R' = H, R2 = CHMeOH; R1 = H, R2 = CMe20H;R' = Me, R2 = CH20H)were synthesized from [PtC12(C2H,)]2, the cyclopropane derivative, and pyridine. The lanthanide shift reagent Eu(fod), was used to simplify the 'H NMR spectra. An attempt has been made to study the conformation of the metallacyclobutane ring in solution on the basis of these NMR spectra. A single-crystal X-ray diffraction study of PtC12(CH2C(CH3)(CH20H)CH2)(C5H5N)2 was carried out. The compound crystallizes in the orthorhombic space group Dii-Pbcu with eight molecules in a cell of dimensions u = i9.596 (7) A, b = 13.893 (5) A, c = 13.108 (5) A, and V = 3569 A3 (t = -151 "C). The final conventional and weighted agreement indices on F,2 are R = 0.056 and R, = 0.086. The metallacyclobutane is puckered by LOo in the solid state and can be compared with a puckering of -27" determined from solution studies on a series of related platinacycles. This difference may be of relevance to olefin metathesis reaction mechanisms.

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The puckering of metallacyclobutanes has been discussed in detail as part of the mechanistic basis of selectivity of transition-metal complexes as catalysts for alkene metathesis.' Although metallacycles have been proposed as intermediates in alkene metathesis, it was only recently2 , that the titanacyclobutanes Ti(C5H5)2(CH2CHRCH2), R , I = t-Bu or Ph, and Ti(C5H5)2(CH2CMe2CH2) were isolated from a well-defined metathesis system and structurally characterized. We assume that stable platinacyclobutanes, the subject of this paper, have structural features similar to those metallacyclobutanes involved in olefin metathesis. Platinacyclobutanes are much less strained than cyclobutane ( 1 5 kcal mol-1 in Pt(I1) derivatives, -12 kcal mol-' in Pt(1V) derivatives, and 26 kcal mol-' in cy~lobutane).~ Both ring puckering in solution and lack of appreciable ring strain may contribute to the importance of metalla-

cycles as intermediates in transition-metal-catalyzed reactions. Since there is a very low activation energy toward puckering of the metallacyclobutane ring (eq l),the pucker

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(1)For reviews see: Leconte, M.; Basset, J. M. Ann. N.Y. Acad. Sci. 1980,383,165-187. Calderon, N.;Lawrence, J. P.; Ofstead, E. A. Adu. Organomet. Chem. 1979,17,449-492.Grubbs, R. H. B o g . Inorg. Chem. 1979,24, 1-50. (2)Lee, J. B.; Gajda, G.J.; Schaefer, W. P.; Howard, T. R.; Ikariya, T.;Straus, D. A.; Grubbs, R. H. J . Am. Chem. SOC.1981,103,7358-7361. (3) Moore, S.S.; DiCosimo, R.; Sowinski, A. F.; Whitesides, G. M.J. Am. Chem. Soc. 1981,103,948-949.

0276-7333/83/2302-l487$01.50/0

angle found in an X-ray structure determination may depend on steric effects or crystal packing f o r c e ~ . ~ ~ ~ - ~ Thus, the degree of puckering of a metallacyclobutane ring in the solid state and in solution may differ. Moreover, for some electron configurations, but not for the 18-electron platinum(1V) complexes, there is the possibility of nonclassical structures (eq 2), intermediate between metallacyclobutanes and metal-carbene-alkene complexes.* (4)Rajaram, J.; Ibers, J. A. J. Am. Chem. SOC.1978, 100, 829-838. (5)Puddephatt, R. J. Coord. Chem. Reu. 1980,33, 149-194. (6) Rappe, A. K.; Goddard, W. A., I11 J. A m . Chem. SOC.1982, 104, 297-299. (7)Klingler, R. J.; Huffman, J. C.; Kochi, J. K. J . Am. Chem. SOC. 1982,104,2147-2157.

0 1983 American Chemical Society

Burton et al.

1488 Organometallics, Vol. 2,No. 11, 1983 I

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The complex Pt(CH2CH2CH2)(2,2'-bipyridyl) shows a planar platinacyclobutane ring in the solid state, but in solution the large coupling constant 3 J ( P t H ) to t h e P-CH2 protons was interpreted in terms of a very facile puckering (eq 1)and short Pt-H contacts.' However, i t is surprising that t h e r e have been no previous a t t e m p t s to estimate equilibrium pucker angles of metallacyclobutanes in solution, since standard NMR techniques have yielded pucker angles in cyclobutane derivatives that are consistent with those found b y o t h e r methods.*" Provided that there is negligible contribution t o the bonding in metallacyclobutanes from nonclassical structures (eq 2), there is n o reason why t h e same technique cannot be used to estimate the pucker angles in metallacyclobutanes, provided that the necessary coupling constants can be determined from the 'H NMR spectra. In this article the syntheses of some platinacyclobutane derivatives with hydroxymethyl substituents are reported. The presence of the donor hydroxyl group and t h e use of a lanthanide shift reagent a i d analysis of t h e otherwise complex 'H NMR spectra. From t h e vicinal 3J(HH) coupling constants and an equation derived b y Karplus12 i t is possible to estimate the conformation of the metallacyclobutane ring in solution. An X-ray structural study I

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of PtC12(CH2C(CH3)(CH20H)CH2)(C5H5N)2 provides complementary data on t h e conformation in t h e solid state. Our results suggest that t h e puckering of the platinacyclobutane ring differs between the solid and solution states.

solution was obtained. The solvent was evaporated and the residue washed with pentane and then recrystallized from dichloromethane-oentane at 0 "c. Comdexes DreDared in this wav were

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the following: $tC12(CH2CH(CH20H)CH2)(C5H5N)z, I: mp 93-95 "C dec. Anal. Calcd for C,,H,,Cl,N,OPt: C. 33.9:, H.,3.7:, N. 5.6. Found: C. 32.3: H. 3.6: N. 5.1. PtCldCHXH-

_- ."

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I

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I

I

I

- 1

L

I

(CHMeOH)CH2)(C5H5N)z, I 1 mp 120-127 "C dec. Anal. Calcd for C15HmC12N20Pt:C, 35.3; H, 3.9; N, 5.5. Found: C, 34.1; H, 4

111: mp 3.5; N, 5.7. PtC12(CH2CH(CMe20H)CH2)(C5H5N)2, 119-120 "C. Anal. Calcd for Cl6Hz2Cl2NzOPt:C, 36.6; H, 4.2;

N, 5.3.

Found:

C, 36.4; H, 4.3; N, 5.2.

PtCl,(CH,CMe-

( C H ~ O H ) C H Z ) ( C ~ H ~IV: N)~ mp , 116-118 "C dec. Anal. Calcd for C ~ ~ H Z O C ~ ~C, N 35.3; ~ O PH,~ 3.9; : N, 5.5. Found: C, 35.2; H, 3.9; N, 5.4.

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Crystallographic Study of PtC12(CH2C(CH3)(CH20H)7

CH,)(C,H@), IV. Colorless crystals suitable for diffraction were grown from dichloromethane-pentane a t 0 "C. Systematic extinctions (Okl, k = 2n + 1; h01, 1 = 2n + 1; hkO, h = 2n + 1) characteristic of space group DiR-Pbca of the orthorhombic system were observed on X-ray photographs taken at room temperature from a crystal mounted in air. The absences observed a t -151 "C on a Picker diffractometer are consistent with the room-temperature results. The density, 1.77 (2) g/cm3, measured a t room temperature by flotation of the crystals in aqueous ZnCl,, is consistent with the density of 1.899 g/cm3 calculated for eight I

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molecules of PtC12(CH2C(CH3)(CH20H)CH2)(CSH5N)2 in the low-temperature cell. A crystal, described by faces (2101, (016), and (016), cut from a larger crystal was mounted directly in a stream of cold dinitrogen Experimental Section gad7 on a four-circle, computer-controlled Picker FACS-1 difThe 'H and 13C NMR spectra were recorded with a Varian fractometer.l* Cell constants a t -151 OC were obtained as deXLlOO spectrometer. Lanthanide shift studies were carried out scribed elsewherelgby a least-squares refinement of 25 centered by adding portions of a weighed sample of Eu(fod), shift reagent reflections in the range 24" < 28(Mo K q ) < 31". The cell con(fod = 1,1,1,2,2,3,3-heptafuoro-7,7-dimethyloctane-4,6-dione) to stants are a = 19.596 (7) A, b = 13.893 (5) A, c = 13.108 (5) A, a solution of a known weight of the platinacyclobutane in CDC13 and V = 3569 A3. solution. Molar ratios were calculated from each spectrum by Data collection and reduction were carried out as described comparison of the integration for the tert-butyl group of Eu(fod), previously.20 A total of 4550 unique reflections was collected in and the integration of an appropriate signal corresponding to the the range 3.5" I28(Mo Kq)I57.0". Six strong reflections were platinacyclobutane. Plots of 6 (ppm) w. Eu(fcd),/substrate (where remeasured every 100 reflections during the course of the data Eu(fod),/substrate < 0.9) are shown in Figure l.13 collection. Their intensities decreased from the initial measured Zeise's dimer [PtCl2(C2H4)I2was prepared by a literature intensities by an average of approximately 15% and the decrease method.l* Most cyclopropanes were commercial samples, but varied from 5 to 25%. An approximate average correction for 2-cyclopropyl-2-propanolwas prepared by reaction of cyclopropyl this decrease was made. Table I presents other parameters methyl ketone with methyl Grignard reagent15 and l-methylrelevant to the data collection process. 1-(hydroxymethy1)cyclopropanewas prepared directly from the Solution and refinement of the structure were carried out by corresponding carboxylic acid by reduction with LiA1H4.lB For standard procedures.20 The position of the platinum atom was deduced from a sharpened, origin-removed Patterson synthesis. CH,CH,C(CH,)(CH,OH): 'QIH) NMR (CDCld 6 70.4 (CHZOH), Full-matrix least-squares refinements and Fourier and difference 20.6 (CH,), 17.9 (CCH,), 10.8 (CHZCH,). Fourier syntheses were used to locate the positions for the reSynthesis of Platinacyclobutanes. To a solution of [Ptmaining non-hydrogen atoms. The function minimized initially Clz(CzH4)]z (0.15 g, 0.26 m o l ) in dry, redistilled tetrahydrofuran was Cw(lFol - IFJ),, where lFol and IF,]are respectively the ob( 5 mL) was added the cyclopropane derivative (0.25 g, -2.5 served and calculated structure amplitudes and where w = mmol). The mixture was allowed to stir for 1 day a t room tem4F,2/2(F,2). Atomic scattering factors were taken from the usual perature in the dark. Then the solution was filtered to remove tabulatione21' Anomalous dispersion terms for the Pt and two insoluble impurities and was evaporated to dryness. The dry pale C1 atoms were included in Fc.21*22 Isotropic refinement was yellow residue was suspended in dichloromethane (5 mL) and continued until the conventional R index was 0.10. An absorption cooled in ice, and pyridine (-3 drops) was added until a clear correction was applied, and the non-hydrogen atoms were allowed to vibrate anisotropically. An ensuing difference electron density (8)Eisenstein, 0.; Hoffmann, R.; Rossi, A. R. J. Am. Chem. SOC.1981, map revealed most of the hydrogen atom positions. All hydrogen 103,5582-5584. McKinney, R. J.; Tulip, T. H.; Thorn, D. L.; Coolbaugh, atom positions, except that of the hydroxy hydrogen, were T. S.; Tebbe, F. N.Ibid. 1981,103, 5584-5586.

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(9)Bothner-By, A. A. Ado. Magn. Reson. 1965,1, 195-316. (10)Wiberg, K. B.;Barth, D. E. J. Am. Chem. SOC. 1969, 91, 5124-5130. (11)Abraham, R. J.; Cooper, M. A.;Indyk, H.; Siverns, T. M.; Whittaker, D. Org. Magn. Reson. 1973,5,373-377. (12)Karplus, M. J. Am. Chem. SOC.1963,85, 2870-2871. The approximation J = A B cos 8 + C cos 28 was used, with coefficients A , B , and C from ref 9. (13)See paragraph at end of paper regarding supplementary material. (14)Chatt, J.; Searle, M. L. Inorg. Synth. 1957,5,210-215. (15)Traas, P. C.; Boelans, H.; Takken, H. J. R e d . Trau. Chim. Pays-Bas 1976,95, 57-66. (16)Roberts, J. D.; Mazur, R. H. J. A m . Chem. SOC. 1951, 73, 2509-2520.

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(17)Huffman, J. C. Ph.D. Thesis, Indiana University, 1974. (18)The disk-oriented diffractometer control program is from: Lenhert, P. G. J. Appl. Crystallogr. 1975,8,568-570. (19)Corfield, P. W.; Doedens, R. J.; Ibers, J. A. Inorg. Chem. 1967,6, 197-204. (20)Jameson, G. B.; Ibers, J. A. J . Am. Chem. SOC.1980, 102, 2823-2831. Doedens, R. J.; Ibers, J. A. Inorg. Chem. 1967,6, 204-210. (21)Cromer, D. T.; Waber, J. T. "International Tables for X-ray Crystallography"; Kynoch Press: Birmingham, England, 1974;Vol. IV, Table 2.2A and 2.3.1.For hydrogen atoms see: Stewart, R. F.; Davidson, E. R.; Simpson, W. T. J. Chem. Phys. 1965,42, 3175-3186. (22)Ibers, J. A.;Hamilton, W. C. Acta Crystallogr. 1964,17,781-782.

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Organometallics, Vol. 2, No. 11, 1983 1489

Substituted Platinacyclobutanes Table I. Sumniary of Crystal Data and Intensity

I I Collection for PtCl2(CH2C(CH3)(CH,OH)CH,)(C,H,N), compd formula fw, amu a, A

b, A c, A

v.A'

2' g/cm3 g/cm3 space group

Pcalcdr Pobsdr

cryst dimens, mm cryst shape cryst vol, mm3 t, "C radiatn linear a b coeff, cm-I transm iss n factors receiving aperture takeoff angle, deg scan speed, deg/min 20 limits scan range background counts unique data used in final refinement unique data, FA2 > 3(; Fo ) final no. of variables R (on Fo2, all data)c R , (on F O 2 , all data) R (on F, for Fo2> 3o(FO2)) error in observn of unit weight a See ref 17. with FO2< 0.

I I PtCI,(CH,C(CH,)(CH,OH)CH,)(C,H,N), C ,H,Cl,N20P t 510.34 19.596 ( 7 ) 13.893 ( 5 ) 13.108 ( 5 ) 3569 8 1.899 (-151 "C) 1.77 ( 2 ) (23 "C) D :i-Pbca

Table 11. Positidnal Parametersa for the Non-Hydrogen Atoms of PtCl,(CH,C(CH,)(CH,OH )CH,)(C,H,N), ATOn

X

Y

.ZCCC,.C.~.???..,++,.?.~~*?.*.~~C~~+.~C...C+..~~~~C.~

Z

0.385642 I 1 3 1

0.156614(151

0.260867(161

0.437354

0 e t 5 4 7 2 (121

G -14146 (121

(

95 I

0.33670 I 1 0 1

0.38440(131

0.29023 ( 3 41

0 e 29995 (65 I

0.48656 ( 2 5 I

0.32849(361

0.39922(291

0.1590 6 I391

0.29171 (351

0.21342 ( € 3 1

0.28686(351

0.28671 (66)

0.35681 ( 3 7 )

0.34202(551

0 28285 ( 3 9 )

c .22727(591

0.19 x 0.26 x 0.80 along direct crystal axes 6-siGd prism with major faces {210), (016), (013) 0.018

0 22719(39l

0 e 36453 (73)

-151' graphite-monochromated M o Ka, h ( M o Kcu,) = 0.7093 A 82.3

4.495731361

0.42997(471

0 429361 4 0

0 190 9 7 ( 6 3 )

0.272-0.409

0.54074( 3 1 1

0.3090 5 ( 6 7 )

0.61 30 1 ( 4 4 1 0 . 5 5 7 4 1 139 I

0.47410 (521

0.41380 (€6)

)

O.C3729(481

0.12814 (57)

0.41385 I 4 8 I

0.02838 ( 5 4 )

0.38479( 541

-il.O0385 ( 5 9 1

0.377961461

4.5 x 6.5 mm; 32 cm from crystal 3.3

2.0 in 28 3.5" =-G 28 G 57.0" 1.0" below Ka, t o 1.35" above Kcu, 10 s at each end of scan with rescan optionb 4550, + h , + k , + l

0~06214(471

Estimated standard deviation in the least significant figure(s) is given in parentheses in this and all subsequent tables. atoms, and Table IV13 presents positional and thermal parameters for all hydrogen atoms. Table V lists values of 1O1F01and 101Fc1;13 a negative entry for lFolindicates F,2 < 0. The root-mean-square amplitudes of vibration are presented in Table VI.13

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Results Syntheses. All known platinum(1V) metallacyclobutanes have either unsubstituted PtCH2CH2CH2rings or have simple alkyl or aryl substituents on the ring. Our early attempts to prepare derivatives with amine functionality failed since reaction of Zeise's dimer with either 2-cyclopropylpyridine or (cyclopropylmethy1)dimethylamine gave only the simple amine complexes trans[PtC12(C2H4)L]. However, we now find that oxygen functionality can be obtained as indicated by the high-yield syntheses of eq 3.

2962 190 0.056 0.086 0.035

R3

I P t C I z ( C 2 H ~ ) l Z-t

1.32 electrons2

See ref 18.

0.26977(471

60 4 78 1 4 11

i n

This includes reflections

idealized (C-H= 0.95 A). The isotropic thermal parameter of a hydrogen atom was assigned to be 1.0 A2 greater than that of the carbon atom to which it is attached. These hydrogen atoms were included as fixed contributions in the final anisotropic refinemenb. The final cycle of least-squares refinement involved minimization of the function Ew(F,2- F:)2, where w = 1/$(F,2), and involved 190 variables and 4550 observations (including those for which FO2 < 0). This refinement converged to final agreement indices (on F :) of R = 0.056 and R, = 0.086. The error in an observation of unit weight is 1.32 e*. The largest peaks in the final difference electron density map are approximately 1.65 (2) e A-3and are associated with the Pt position. The conventional R index on F, for those 2962 reflections having F: > 30(F:) is 0.035. Analysis of Cw(F2- F:)2 as a function of Miller indices, F ,: and setting angles revealed no unexpected trends. The final positional parameters of all non-hydrogen atoms are listed in Table 11. Table 11113presents thermal parameters for the non-hydrogen

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