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Food and Beverage Chemistry/Biochemistry
Germinated Brown Rice Attenuates Atherosclerosis and Vascular Inflammation in Low-Density Lipoprotein Receptor-Knockout Mice Ruozhi Zhao, Nora Ghazzawi, Jiansu Wu, Khuong Le, Chunyang Li, Mohammed H. Moghadasian, Yaw L. Siow, Franklin Apea-Bah, Trust Beta, Zhengfeng Yin, and Garry Shen J. Agric. Food Chem., Just Accepted Manuscript • DOI: 10.1021/acs.jafc.8b00005 • Publication Date (Web): 16 Apr 2018 Downloaded from http://pubs.acs.org on April 16, 2018
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Journal of Agricultural and Food Chemistry
jf-2018-00005b R2
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Germinated Brown Rice Attenuates Atherosclerosis and Vascular
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Inflammation in LDL Receptor-Knockout Mice
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Ruozhi Zhao1, Nora Ghazzawi2, Jiansu Wu3, Khuong Le2, Chunyang Li4,
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Mohammed H. Moghadasian2, Yaw L. Siow4, Franklin B. Apea-Bah2
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Departments of Internal Medicine1, and Food and Human Nutritional Sciences2,
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University of Manitoba, Canadian Centre for Agri-Food Research in Health Medicine4,
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Winnipeg, MB, Canada
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Jiangsu Ruiguanlong Ecological Agricultural Science and Technological Center3,
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Institute of Farm Product Processing, Jiangsu Academy of Agriculture and Sciences5,
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Nanjing, Jiangsu, China
Trust Beta2, Zhengfeng Yin3, and Garry X. Shen1, 2
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Corresponding author:
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Garry X. Shen MD PhD
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Diabetes Research Group
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University of Manitoba
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835-715 McDermot Ave
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Winnipeg, MB R3E 3P4Canada
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Tel: 204-789-3816
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Fax: 204-789-3987
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Email:
[email protected] 1 ACS Paragon Plus Environment
Journal of Agricultural and Food Chemistry
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Abstract
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The present study investigated the impact of germinated brown rice (GBR) on
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atherosclerosis and underlying mechanism in low-density lipoprotein receptor-knockout (LDLr-
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KO) mice. The intensity of atherosclerosis in aortae of LDLr-KO mice reeiving diet
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supplemented with 60% GBR (weight/weight) were significantly less than that in mice fed with
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60% of white rice (WR) or control diet (p
