News for the intact trimer; popolysacchara signal was obides. The diftained in the matriference ces made of ferulic between the acid dissolved in masses of the tetrahydrofuran and protein peak nicotinic acid disand those of solved in water, althe adjacent though the S/N was peak on the better for ferulic high mass side acid. agreed with the mass of a When urea was single lipoused as the matrix polysaccharide for IR-MALDI of chomolecule. The lesterol esterase, researchers the signal for the found that the sole protein was obpresence of detained with good IR-MALDI mass spectra of cholesterol tergents mass resolution; esterases in urea (top) and succinic acid causes signal thus, urea was the (bottom). (Adapted with permission of John decrease and preferred matrix for Wiley & Sons.) peak broadenaccurately detering; thus nonionic detergents should be mining the mass of the protein. When sucused if a subsequent MALDI analysis is cinic acid was used as the matrix, the planned. (J. Mass Spectrom. 1995, 30, spectrum showed a distribution of protein 1462-68) complexes with a varying number of li-
GOVERNMENT
Environmental sensor workshop and forum
Attending Pittcon this year? Then you may want to arrive in Chicago a few days early. Beginning Friday, March 1, the Department of Energy (DOE) and Ames Laboratory (Iowa State University) will sponsor a two-day workshop on chemical sensors for environmental applications, followed on Sunday, March 3, by a speaker's forum on the same topic. According to Glenn Bastiaans of Ames Laboratory, the workshop and forum are part of a larger DOE effort to discover and promote new technologies that will support or lower the costs of the department's massive environmental cleanup program. Workshop participants will discuss developing, adapting, and commercializing new analytical technologies, and the sponsors hope to attract users, developers, and manufacturers of chemical sensors and fielddeployable instrumentation. In addition, the results of a recent market survey exfor use in MEKC. In an effort to make New chiral more chiral micelles available to the chro- ploring the use of and need for chemical surfactants for sensors will be unveiled at the workshop. matographer, Desmond D. Dalton and MEKC colleagues at UMIST (U.K.) and SmithBastiaans anticipates that some of the Kline Beecham Pharmaceuticals (U.K) technologies required by DOE are comTo effect chiral separation in micellar elec- have synthesized two new chiral surfacmercially attractive. Thus, the federal govtants, referred to as NaC10 and NaC12, trokinetic capillary chromatography ernment can accelerate the development (MEKC), one must use either a chiral sur- from (R,R) -tartaric acid and long-chain ali- by facilitating the transfer of these technolphatic amines. factant or a micelle that includes a chiral ogies to commercial manufacturers. molecule, such as sodium dodecyl sulfate Other technologies are almost exclusive to They first determined critical micelle (SDS) with either digitonin or sodium Nconcentrations of ~ 2.6 mM for NaC10 and dodecanoyl-L-valinate (a mixed micelle). ~ 2.4 mM for NaC12 by plotting surface Other than SDS-based mixed micelles, tension versus concentration and then perfew chiral micelles have been developed formed electrophoretic separations for eight different compounds. They found that those with fused polyaromatic rings are more easily separated than those with only a single aryl group. A possible explanation is that the separation occurs because of stronger inclusion within the micelle caused by the fused polyaromatic rings. (J. DOE wants a few good technologies— Chromatogr. A such as SEAMIST, a liner covered with 1995, 712,365Enantiomeric separation of compound shown. (Adapted with sensors and fluid samplers that is used to 71) permission of Elsevier Science.) monitor wells. 18 A
Analytical Chemistry News & Features, January 1, 1996
DOE's needs, and development may require full funding support from the government. "It's a reality check—where we are in development and where we're going," says Bastiaans. For more information on the workshop and forum, contact Bastiaans at 515-2943298 or by e-mail at bastiaans@ameslab. gov. Program information, as well as news and events pertaining to DOE's characterization, monitoring, and sensor technology program, can be found on the World Wide Web at http://cmst.ameslab.gov/ cmst/homepage.html.
Atomic spectroscopy database available Thefirstatomic spectroscopy database from the National Institute of Standards and Technology (NIST), designed for use on PCs, is a comprehensive collection of accurate and critically evaluated spectra that contains wavelengths (1-200,000 A), transition probabilities, and energy levels for most ionization stages of 28 elements. The database should be useful to chemists, astronomers, physicists, geologists, and industry researchers. Users can search by wavelength, energy level, or element and can change default options for units, output, and other parameters. Cost is $215. For information, contact the Standard Reference Data Program, NIST, A320 Physics Bldg., Gaithersburg, MD 20899-0001 (301-975-2208; fax 301-926-0416; email
[email protected]).
PEOPLE
N e w Advisory Board and A-page Advisory Panel members appointed Advisory Board Five new members from government, academia, and industry have been selected to serve three-year terms on Analytical Chemistry's Editorial Advisory Board. Each January, membership is rotated as new appointees replace members whose terms have expired. In addition to the 16 appointed members, the chairperson of the ACS Division of Analytical Chemistry serves a one-year term as ex officio representative of the Division. Established in the 1940s to advise the journal's editors, the board meets formally once a year at ACS headquarters. The board members are a vital link between the editors and the analytical chemistry community, providing guidance and advice on editorial content and policy. Henry N. Blount, program director for Analytical and Surface Chemistry at the National Science Foundation (NSF) and 1995 chairman of the Division of Analytical Chemistry, will serve as ex officio representative for an additional year because this year's chairman, Edward S. Yeung, is Analytical Chemistry's Associate Editor for spectroscopy. Blount received his B.S. degree from the University of North Carolina and his Ph.D. from the University of Georgia and has been at NSF since 1984.
Mary Ellen P. McNally, research associate at DuPont's Experimental Station, received her Ph.D. from Villanova University in 1983 and held a postdoctoral position at the University of Georgia with Buck Rogers. She joined DuPont in 1985 and performs research in SFE, SFC, LC and micro LC, and CZE applied to the environmental fate of agricultural products and ultratracelevel detection and analysis. Donald G. Patterson, Jr., chief of the Dioxin and Related Compounds Laboratory at the Centers for Disease Control and Prevention (CDC), received his Ph.D. from Arizona State University in 1975 and joined CDC in 1979. He is interested in using on-line hyphenated MS techniques to assess human exposure to environmental toxicants by measuring the parent compounds and metabolites in blood and urine. Marc Porter, associate professor at Iowa state University ind senior scientist itAmesLabora:ory, received his B.S. and M.S. decrees from Wright state University ind his Ph.D. from Ohio State University. His research interests include organic thin films, spectroscopic and scanning probe microscopic surface characterization techniques, chemical sensors, and electrochemically modulated LC.
N e w NSF manual The National Science Foundation (NSF) has published an updated version of its Grant Policy Manual (NSF 95-26) that supersedes the earlier version and its amendments. The manual, condensed and reorganized to follow the NSF award cycle, is available electronically on NSF's Science and Technology Information System and will eventually be available on the NSF home page (http://www.nsf. gov). For information, contact the Policy Office at 703-306-1243 (e-mail policy ©nsf.gov).
Jiri Janata, associate director of the Tsuguo Sawada, professor of applied Environmental Mochemistry at the lecular Science University of ToLaboratory at Pakyo, received his cific Northwest B.E. and M.E. deLaboratory, regrees in 1965 and ceived his Ph.D. in 1967, respectively, analytical chemand his Ph.D. in istry from Charles 1970 from the UniUniversity (Prague, Czech Republic) in versity of Tokyo. His research interests in1965. His research interests include chem- clude developing photoacoustic, photoical sensors and electroanalytical chemisthermal, and laser-applied spectroscopies try, with an emphasis on environmental ap- and evaluating materials using optical plications. methods. Analytical Chemistry News & Features, January 1, 1996 19 A
