Grignard reactions of nonmetallic substances - Journal of Chemical

Henry Gilman. J. Chem. Educ. , 1955, 32 .... Drug hunters have spent years cutting chemical keys to fit the most obvious biological locks: a protein's...
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JOURNAL O F CHEMICAL EDUCATION GRIGNARD REACTIONS OF NONMETALLIC SUBSTANCES

20 pp; and a very general chapter on chromatography in industry, 7 pp. There is a. bibliography of 17 reference books and reviews, and a short index. M. S.Khamsch, Professor of Chemistry, and Otto Reinmuth, The book deals with elements of chromatography, and only Research Associate, University of Chicago. Prentiee-Hall, Inc., with some of these. Writing in a straightforward style, the New York, 1954. lodi 1384 pp. 87 tables. 16 X 23.5 cm. author conveys to the reader thst chromtography is a rather $15. simple yet powerful analytical tool. This should encourage THEinitial paragraph of the preface to this excellent hook reads many chemists t o become acquainted with chromatography. as follows: "It is reported that Sir William Osler used to open If this book will not carry them very far in the solution of new certain of his lectures to medical classes a t The Johns Hopkins problems, that is not its purpose (as indicated by its title), snd with the statement thst he who knows syphilis know# medicine, a t the end of each chapter there m e s. few selected references to for its srmptnma rnn ~imul.ttrthow of any tlisrwr in rhr t~:tt,!loe. aid the reader in pursuing that particular subject further. The \Gth lmt little nmrr pwric lirewr thsu the p o d dortor perntit1t.d book is printed on good paper and the color reproductions are very pleasing. They have the great advantage of photographs tlx hinurlf, if nninlrt lx. said thit IN. who knosti and undrml~r~clu ~ r i g n a i dreac'iions has a fair grasp of organic chemistry, for most that, being true to fact, they show that in real chromatography fundamental processes have prototypes or analogs in phenomena not d l eones are straight and sharp, nor all spats on paper clearly separated and well defined. This adds greatly t o the pleasure observable in Grignard systems." The first five chapters of this book are: Historical Introduc- of reading the hook, and also t o the encouragement i t ~hould tion; The Preparation of Grignard Reagents; Estimation and De- give to an inexperienced chromatographer. tection of Grignard Reagents; Constit,ution and Di~sociationof HAROLD G. CASSIDY Grignard Reagents; YALEUNWERB~TT . and Some Radical Reactions of Grignard ~eigents. N e w HAYEN.CONNECT~CDT Chapter 6 ia devoted to Reactions of Grignard Reagents with Aldehydes, Ketones, and Ketenes. Then follows a series of chapters concerned with reactions of Grignard reagents with compounds having the widest variety of functional groups. Some other chapters are: Allylic Rearrangements in Grignard Reac- 0 ELECTROPLATING ENGINEERING HANDBOOK tions; and The Tschugxff-Zexwitinoff Method for the DeterA. Kenneth Grohom and H.L. Pinkerfon. Rainhdd Edited by mination of "Active" Hydrogen. The Index of Grignard Reagents 650 pp. Many extends over 16 pages, and the General Index comprises 22 pages. Publishing Corporation, New York, 1955. xir This monumental work is one of the most comprehensive vol- figs. and tables. 18 X 2 6 om. $10. umes in any segment of organic chemistry. I t is altogether reaELECTROPLATING in the past hits been largely a collection of sonable to expect that in a first edition of so tremendous an undertaking there would he errors and omissions. However, the errors farnubs for plitting baths, usually not even arranged hy chemical type. Now we have a. handbook that presents the engineering are, on the whale, neither numerous nor serious, and will undoubtedly be corrected in another printing or edition. The authors asperts of the electroplating industry-probably one of the most elected to choose those references which should be included, and widely disseminated chemical industria. The "Handbook" is divided into two sections; the first is on t1w refrrenvw not inrludrcl m:ry not he imporrsrrt. Tht. work i~ vomrtltinc more fhnn x mrrr i~ollrcriuua d dimst generd processing data (391 pp.), whereas the second contains engineering fundamentals and practice (230 pp.). Useful nf thio vurt literatuw. Thcw will iurnlrdrtrdlv tar rcadrrri who arc the glossary which defines the terms used in the pages features will not agree with some of the observations and ideas presented hv the authors. However. the oocitsional intemolations and SUE- that follow, and the first chapter that tabulates many data of ,~ gestions of the xufl~omIIHW the merit that tlyy enliwn the prw- importance in electrochemistry. Part I, on general processing drtts, presents methods and e q u i p entntion in sornr pl:ws arid indirnfr prohlems h ~ r v i n gad& ment used in the nlatine nrocess: surface nreosr&m and tional study. The number of classics in organic chemistry is not large. This work has every promise of becoming a classic, and organic chemists are deeply indebted to the authors. beyond thin usual material in containing chapters on water HENRY GILMAN requirements, waste disposal, industrial hygiene and safety, and metallurgy for the electroplater. The short chapter entitled Trouble Shooting is most interesting and could have been extended with benefit to dl. Part 11. on eneineedne- fundamentals and oraebice. deals with plant and pndwrirm er,~inwringpnhlenls, such as p l ~ u ln(.afion f and lnwut, trrnka, liroinai, ror>tinuo~rsequipnlerlt, automntir 0 THE ELEMENTS OF CHROMATOGRAPHY equipment, exhaust systems, rectifiers, filtration, maintenance, Trevor Illtyd Williams. Blaclde & Son, Ltd., London, 1954. and the like. Design features, calculation methods, curves, and vii 9 0 pp. 36 figs. Tables. 13 X 19 cm. 916. data me given. The book has a large page size (like Peny's "Chemical EnTHIShook is designed by the author as a general survey for university students and research workers, of chromatographic gineers' Handbook") so that a double-column page permits methods in use today. When one realizes that a recent book on raoid resdine as well as laree illustrations. The list of 43 oanpaper chromatography is 720 pages long and contains some 3795 tibutom who wrote indivi&al chapters in the areas of their references, it must be recognized as s n accomplishment that speeislties is a. "Who's Who" in electroplating. This handbook becomes the standard reference source to the Dr. Williams (Deputy Editor of Endeavor) has managed to comprocess and engineering features of electroplating. College Dress information on most fields d chromatography into 90 pages. courses in electrochemistry should make their students familiar t'igur~axrld rwrllmt color pbrr* h d p a meat deal. T ~ first P rltaptrr (10 pp.) givrs a l,nlsnml historical i n t w with it. Plant and process design courses should consider the duct ion to vhromntoeranhv, retlrr tine tlor srhalarlv work that I h . electroplating industry as one of the widespread chemical William and Weil Cavk dine in thig area. ~ d s & t i o n chroma- industries. tography is given 21 pp.; partition chromatography, including s. KENNETH A. KOBE discussion of the separation of inorganic ions, 18 pp.; ionexchange chromatography, 7 pp.; three chapters on techniques, 0

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