July, 1964
BOOKREVIEWS
575
with a stream of dry nitrogen. A solution of 11 g. (0.027 mole) lization from ether provided an analytical sample in the form of of acetobromoglucose in 65 nil. of methanol was then added colorless needles, m.p. 180-181°, [ a I z 4 D -41' ( c 1.3, ethanol). dropwise a t a rapid rate to the stirred solution while maintaining Anal. Calcd. for ClaHlsBrCINOs: C, 41.15; H, 3.70; N, an external temperature of 0". After 18 hr., during which time 3.43. Found: C, 41.00; H, 3.89; K, 3.45. the reaction mixture was allowed to reach room temperature, 5-Bromo-4-chloro-3-indo~y~-~-~-galactopyranos~de crystalthe solvent was evaporated in vacuo a t ca. 30". The viscous lizes as an amorphous solid from methanol, m.p. 237-239' dec., yellow oil that remained solidified slowly on stirring with water [ c z ] * ~ D-69" ( C 1.0, 5070 DRIF). and the dark product was collected and sucked dry. The filter Anal. Found: C, 41.24; H, 3.78; N, 3.63. cake was stirred with cold acetone which removed most of the 5-Bromo-6-chloro-3-indolyl-P-~-glucopyranoside crystallizes dark material, leaving an off-white solid, 2.6 g. (2iffe,rentor contrary opinions on t,he S R I I I ~suhject arr evaluated criticallj- by the diBerent authors. For esaniple, t,he role of ACH i n asonal conduction of nerve impulse is discussed by threc wintributors-Nachmansohn, Heth, and Koelle. The three authors :irrive a t different ronclusions and. thus, :I certain degree of overlapping has served a useful purpose. This volume should he of great interest r i i ~ toiily to rese:rrc.li ph:mnacologists arid to research workers i n related disciplines, but :tlso to entomologists and environniental health scientists. IIinvever, i t should he pointed out, that, :tlthi~ught,he I)uok deals mainly with antiCHE compijunds, ni:tny of n-liich are used as insecticides, very little spilce is allotted t(J :L discussion uf the insect's nervous system, thc. role of ACH--CHIr :il,strart :wtirles from :ill major and standard j o u r i d s , 450 jourii:ilP so f:tr, in t,he following areas: I)iopharniaceutirs, 1)hysic:rl pIi:ir~nai'y,pharin:ic~c~iitical technology, pharmaceutid chemistr> , investig:ttional drugs. drug evaluations, adverse drug I:tivs :tnd regulations, and the history, c:tliii,s, sociology, and litrr:ttnri~o f drugs. Thwc !vi11 l i e :Lt,I ( w 1 0000 7 7
ti,ts o f li'g:iI, t r : i i I i ~ , alii1 pro IVtiile t,hrrr will IIPsiini(' ovrrla.pping with Cht-miccrl ,i hstrtrct.i. t.he collection of :tbst r:ii,ts o f tlledicinal and pharmareuticd int,erest under one iuiver, :ind the promised rapid appeurnncr of' :i'ristract,sa,ft,cJrp ~ i t i l i ~ ~ t ii ~ i f nthr i i .jiiiirnal articles sho~iltiprrsii:idt~ :in). scientist i n tlir ficlil. :iiiiI: i l l profcssiiinal pharrri:ic~ists,i o rwcl this \ v c l c o t i i t ~i i ~ i v~irg:iti.
