EDITOR
HANS NEURATH, University of Washington
Published by the AMERICAN CHEMICAL SOCIETY
1155 16th Street, N.W. Washington, D. C. 20036 BOOKS AND JOURNALS DIVISION ASSOCIATE EDITORS
Milton P. Gordon, University of Washington Edmond H. Fischer, University of Washington William W. Parson, University of Washington
John Κ Crum R u t h Reynard
Director Assistant to the Director
Charles R. Bertsch Head, Editorial Processing Department D . H . Michael Bowen Head, Journals Department Bacil Guiley Head, Graphics and Production Department Seldon W. Terrant Head, Research and Development Department
EDITORIAL ADVISORY B O A R D
Robert H. Abeles, Brandeis University Konrad Bloch, Harvard University Paul D. Boyer, University of California, Los Angeles Ludwig Brand, Johns Hopkins University W. Wallace Cleland, University of Wisconsin Roger D. Cole, University of California, Berkeley Jack Gorski, University of Illinois Irwin C. Gunsalus, University of Illinois Lowell P. Hager, University of Illinois William F. Harrington, Johns Hopkins University F. M. Huennekens, Scripps Clinic & Research Foundation Irving M. Klotz, Northwestern University Daniel E. Koshland, University of California, Berkeley Marian E. Koshland University of California, Berkeley Edwin G. Krebs, University of California, Davis Michael Laskowski, Jr., Purdue University Albert L. Lehninger, Johns Hopkins University Nelson J. Leonard, University of Illinois Albert S. Mildvan, Institute for Cancer Research, Philadelphia Kivie Moldave, University of California, Irvine Mary Jane Osborne, University of Connecticut William D. Phillips, Du Pont Experimental Station Joanne Ravel, University of Texas Phillips W. Robbins, Massachusetts Institute of Technology Irwin A. Rose, Institute for Cancer Research, Philadelphia Harold A. Scheraga, Cornell University S. Jonathan Singer, University of California, San Diego Earl R. Stadtman, National Heart Institute Ignacio Tinoco, Jr., University of California, Berkeley Paul O. P. Ts'o, Johns Hopkins University Bert L. Vallee, Harvard University Κ. Ε. Van Holde, Oregon State University Finn Wold, University of Minnesota Medical School SECRETARY OF T H E B O A R D
Warren E. C. Wacker, Harvard Medical School
2A
BIOCHEMISTRY,
VOL.
13,
NO.
2,
1974
© Copyright, 1974, by the American Chemical Society. Published biweekly by the American Chemical Society at 20th and N o r t h a m p t o n Streets, Easton, Pennsylvania. Second-class postage paid at Washington, D . C., and at additional mailing offices. Manuscripts for publication and correspondence regarding accepted papers should be sent to the Editor, H a n s Neurath, University of Washington, Seattle, Washington 98195. Proof, edited manuscripts, and reprint orders should be sent to Editorial Processing Department, American Chemical Society, 20th and N o r t h a m p t o n Streets, Easton, Pa. 18042. Head, Charles R. Bertsch. Senior Production Editor: Mari anne C. Brogan. Assistant Editors: Patricia A. Bronko and D e b o r a h A. Wilson. Editorial Assistant: Holley A. Stewart. Advertising Office: Centcom, Ltd., 142 East Avenue, Norwalk, Con necticut 06851. The American Chemical Society and the Editors of Biochemistry assume no responsibility for the statements and opinions advanced by contributors to this joural. Business and Subscription Information Send all new and renewal subscriptions with payment to : Office of the Controller, 1155 16th Street, N . W . , Washington, D . C. 20036. Subscrip tions should be renewed promptly to avoid a break in your series. All correspondence and telephone calls regarding changes of address, claims for missing issues, subscription service, the status of records, and accounts should be directed t o : Manager, Membership and Subscription Services, American Chemical Society, P.O. Box 3337, Columbus, Ohio 43210. Telephone (614) 421-7230. On changes of address, include both old and new addresses with ZIP code numbers, accompanied by mailing label from a recent issue. Allow four weeks for change to become effective. Claims for missing numbers will not be allowed (1) if loss was due to failure of notice of change in address to be received before the date above, (2) if received more t h a n sixty days from date of issue plus time normally required for postal delivery of journal and claim, or (3) if the reason for the claim is "issue missing from files." Subscription rates for 1974: to members, $20.00 per year; to nonmembers, $60.00 per year. Those interested in becoming members should write to the Admissions Department, American Chemical So ciety, 1155 Sixteenth St., N . W . , Washington, D. C. 20036. Postage to Canada and countries in the Pan-American Union, $5.00; all other coun tries, $6.00. Air freight rates available on request. Single copies: for current year, $3.00. Rates for back issues and volumes are available from Special Issues Sales Department, 1155 Sixteenth St., N.W., Washington, D . C. 20036. Subscriptions to this and the other ACS periodical publications are available on microfilm. For information on microfilm subscriptions, write Special Issues Sales Department at the address above.