Identification of a Novel TRPM8 Agonist from Nutmeg: A Promising

May 31, 2017 - Synthetic and natural l-(−)-menthol is the TRPM8 agonist with the most widespread use as an additive in food, drinks, tobacco, cosmet...
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Identification of a Novel TRPM8 Agonist from Nutmeg: A Promising Cooling Compound Tomohiro Shirai,*,† Kentaro Kumihashi,† Mitsuyoshi Sakasai,‡ Hiroshi Kusuoku,‡ Yusuke Shibuya,‡ and Atsushi Ohuchi† †

Kansei Science Research and ‡Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-Machi, Haga-Gun, Tochigi 321-3497, Japan S Supporting Information *

ABSTRACT: The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary receptor for innocuous cold stimuli (