Identification of a Novel TRPM8 Agonist from Nutmeg: A Promising

May 31, 2017 - ACS eBooks; C&EN Global Enterprise. A; Accounts .... Identification of a Novel TRPM8 Agonist from Nutmeg: A Promising Cooling Compound...
0 downloads 0 Views 2MB Size
Letter pubs.acs.org/acsmedchemlett

Identification of a Novel TRPM8 Agonist from Nutmeg: A Promising Cooling Compound Tomohiro Shirai,*,† Kentaro Kumihashi,† Mitsuyoshi Sakasai,‡ Hiroshi Kusuoku,‡ Yusuke Shibuya,‡ and Atsushi Ohuchi† †

Kansei Science Research and ‡Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-Machi, Haga-Gun, Tochigi 321-3497, Japan S Supporting Information *

ABSTRACT: The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary receptor for innocuous cold stimuli (