Identification of Potent and Selective Amidobipyridyl Inhibitors of

Identification of Potent and Selective Amidobipyridyl Inhibitors of

Jul 14, 2010 - ... Nikos Pagratis, Margaret Pancost, Anup Patnaik, Dillon Phan, Craig Plato, ... Bradley S. Ferguson, Michael F. Wempe, Timothy A. McKinsey.


Jul 14, 2010 - (2) Specifically, left ventricular hypertrophy is an independent risk factor for cardiac disease.(3) Given that heart failure(4) continues to be a ...


Jul 14, 2010 - mean arterial pressure; PMA, phorbol 12-myristate 13-acetate; PE, pheny- ..... 53, No. 15. Meredith et al. Table 1. PKD Inhibition (IC50, nM) and HDAC5 Export .... N HCl, 90% Captisol in pH buffer (10%); AUC is 0-24 h. c Below quantita


Jul 14, 2010 - ... Karl Miranda,â Nikos Pagratis,â¡ Dillon Phan,â¡ Craig Plato,â¡ Chang Rao,â ... Street, Boulder, Colorado 80301, and Â§Novartis Institutes for ...

Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of

Arthritis and Bone Metabolism Research, Novartis Pharmaceuticals Corporation, 556 Morris Avenue, Summit, New Jersey 07901. J. Med. Chem. , 2001, 44 ...... Regis Leung-Toung , Jolanta Wodzinska , Wanren Li , Jayme Lowrie , Rahul Kukreja , Denis Desile

The Identification of Potent, Selective, and Orally Available Inhibitors of

Apr 23, 2018 - The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of ...

Identification of Potent and Selective Mechanism-Based Inhibitors of

Dec 29, 2001 - The Available Chemical Directory. Prashant V. Desai, Akshay Patny, Jiri Gut, Philip J. Rosenthal, Babu Tekwani, Anuradha Srivastava, and .... Use of cysteine-reactive small molecules in drug discovery for trypanosomal disease. Deborah

Identification of Potent and Selective Non-covalent Inhibitors of the

Sep 16, 2014 - therapeutic window in culture compared with our in vitro data using purified enzymes (Table 1). In particular, five compounds showed greater than .... a National Science Scholarship from the Agency of Science,. Technology and Research,

Identification of Potent and Selective Inhibitors of PDGF Receptor

Toshiyuki Shimizu , Kaname Kimura , Teruyuki Sakai , Kazuki Kawakami , Tetsuko Miyazaki , Masayoshi Nakouji , Akira Ogawa , Hitomi Ohuchi and Kiyoshi ...

Identification of Potent and Selective Small-Molecule Inhibitors of

Oct 15, 2002 - Identification of Potent and Selective Small-Molecule Inhibitors of Caspase-3 through the Use of Extended Tethering and Structure-Based Drug Design .... Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective an

Identification of Potent and Selective Amidobipyridyl Inhibitors of

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