Article pubs.acs.org/Biomac
Immobilization of Coacervate Microcapsules in Multilayer Sodium Alginate Beads for Efficient Oral Anticancer Drug Delivery Chao Feng,† Ruixi Song,† Guohui Sun,† Ming Kong,† Zixian Bao,† Yang Li,† Xiaojie Cheng,† Dongsu Cha,‡ Hyunjin Park,*,‡ and Xiguang Chen*,† †
College of Marine Life Science, Ocean University of China, Yushan Road, Qingdao 266003, Shandong Province, People’s Republic of China ‡ Graduate School Biotechnology, Korea University, 1,5-Ka, Anam-Dong, Sungbuk-Ku, Seoul 136-701, South Korea S Supporting Information *
ABSTRACT: We have designed and evaluated coacervate microcapsules-immobilized multilayer sodium alginate beads (CMs-M-ALG-Beads) for oral drug delivery. The CMs-M-ALGBeads were prepared by immobilization of doxorubicin hydrochloride (DOX) loaded chitosan/carboxymethyl coacervate microcapsules (DOX:CS/CMCS-CMs) in the core and layers of the multilayer sodium alginate beads. The obtained CMs-M-ALGbeads exhibited layer-by-layer structure and rough surface with many nanoscale particles. The swelling characteristic and drug release results indicated that 4-layer CMs-M-ALG-Beads possessed favorable gastric acid tolerance (the swelling rate F
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