Article pubs.acs.org/Langmuir
Impact of Structural Differences in Galactocerebrosides on the Behavior of 2D Monolayers Cristina Stefaniu,*,† Annika Ries,‡ Olof Gutowski,§ Uta Ruett,§ Peter H. Seeberger,†,∥ Daniel B. Werz,⊥ and Gerald Brezesinski*,† †
Max Planck Institute of Colloids and Interfaces, Science Park Potsdam-Golm, 14476 Potsdam, Germany Georg-August-Universität Göttingen, Institute of Organic and Biomolecular Chemistry, Tammannstr. 2, 37077 Göttingen, Germany § DESY, Forschungsbereich FS, Notkestr. 85, 22603 Hamburg, Germany ∥ Freie Universität Berlin, Institute of Chemistry and Biochemistry, Arnimallee 22, 14195 Berlin, Germany ⊥ Technische Universität Braunschweig, Institute of Organic Chemistry, Hagenring 30, 38106 Braunschweig, Germany ‡
S Supporting Information *
ABSTRACT: The molecular interactions of three biologically important galactocerebrosides have been studied in monolayers formed at the soft air/ water interface as 2D model membranes. Highly surface-sensitive techniques as GIXD (grazing incidence X-ray diffraction), IRRAS (infrared reflection− absorption spectroscopy), and BAM (Brewster angle microscopy) have been used. The study reveals that small differences in the chemical structure have a relevant impact on the physical−chemical properties and intermolecular interactions. The presence of a 2-D-hydroxyl group in the fatty acid favored for GalCer C24:0 (2-OH) monolayers a higher hydration state of the headgroup at low lateral pressures (
