In AC Research: In AC Research - Analytical Chemistry (ACS

Publication Date (Web): September 1, 2002. Cite this:Anal. Chem. 74, 17, 447 A-452 A. Note: In lieu of an abstract, this is the article's first page. ...
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in ac research

In AC Research contains brief introductions to the research articles appearing in the September 1 issue plus a partial listing of articles tentatively scheduled for September 15. A free updated table of contents is available on the Web (http://pubs.acs.org/ac).

ACCELERATED ARTICLES Watching chemical reactions. Joel Harris and colleagues at the University of Utah have developed an inverted confocal Raman microscope to study chemical reactions on single, optically trapped particles and applied it to reactions used in solid-phase peptide synthesis. Spectra of the time-varying species as they bind to or cleave from the solidphase support particle surface can be resolved using twodimensional least-squares methods. (“Confocal Raman Microscopy for Monitoring Chemical Reactions on Single

BIOANALYTICAL ELFSE at work. Annelise E. Barron and colleagues at Northwestern University present a method for multiplexed single-base extension genotyping that takes advantage of the unique separation modalities made possible by end-labeled free-solution electrophoresis (ELFSE). The study is designed to demonstrate multiplexed single-nucleotide polymorphism genotyping of several loci in a single reaction and a single subsequent analysis. The analysis is conducted without any viscous polymeric separation media, is completed in