Subscriber access provided by the Henry Madden Library | California State University, Fresno
Article
Increased Iron Deposition on Brain Quantitative Susceptibility Mapping Correlates with Decreased Cognitive Function in Alzheimer's Disease Lei Du, Zifang Zhao, Ailing Cui, Yijiang Zhu, Lu Zhang, Jing Liu, Sumin Shi, Chao Fu, Xiaowei Han, Wenwen Gao, Tianbin Song, Lizhi Xie, Lei Wang, Shilong Sun, Runcai Guo, and Guolin Ma ACS Chem. Neurosci., Just Accepted Manuscript • DOI: 10.1021/acschemneuro.8b00194 • Publication Date (Web): 03 May 2018 Downloaded from http://pubs.acs.org on May 4, 2018
Just Accepted “Just Accepted” manuscripts have been peer-reviewed and accepted for publication. They are posted online prior to technical editing, formatting for publication and author proofing. The American Chemical Society provides “Just Accepted” as a service to the research community to expedite the dissemination of scientific material as soon as possible after acceptance. “Just Accepted” manuscripts appear in full in PDF format accompanied by an HTML abstract. “Just Accepted” manuscripts have been fully peer reviewed, but should not be considered the official version of record. They are citable by the Digital Object Identifier (DOI®). “Just Accepted” is an optional service offered to authors. Therefore, the “Just Accepted” Web site may not include all articles that will be published in the journal. After a manuscript is technically edited and formatted, it will be removed from the “Just Accepted” Web site and published as an ASAP article. Note that technical editing may introduce minor changes to the manuscript text and/or graphics which could affect content, and all legal disclaimers and ethical guidelines that apply to the journal pertain. ACS cannot be held responsible for errors or consequences arising from the use of information contained in these “Just Accepted” manuscripts.
is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Published by American Chemical Society. Copyright © American Chemical Society. However, no copyright claim is made to original U.S. Government works, or works produced by employees of any Commonwealth realm Crown government in the course of their duties.
Page 1 of 31 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60
ACS Chemical Neuroscience
1
Increased Iron Deposition on Brain Quantitative Susceptibility
2
Mapping Correlates with Decreased Cognitive Function in
3
Alzheimer's Disease
4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41
Lei Du1#, Zifang Zhao,2#, Ailing Cui3#, Yijiang Zhu4, Lu Zhang5, Jing Liu1, Sumin Shi1, Chao Fu1, Xiaowei Han1, Wenwen Gao1, Tianbin Song6, Lizhi Xie7, Lei Wang8, Shilong Sun1, Runcai Guo1, and Guolin Ma1* #
These authors contributed equally Corresponding authors: Guolin Ma, Ph.D., Department of Radiology, China-Japan Friendship Hospital, No.2 East Yinghua Road, Chaoyang District, Beijing, China 100029, Phone: +86 13161338115, E-mail:
[email protected] ∗
Affiliations： ： 1 Department of Radiology, China-Japan Friendship Hospital, Beijing, China. 2 Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China. 3 Anatomy Department, Changzhi Medical College, Changzhi, Shanxi, China. 4 Department of Imaging, ANHUI Provincial Hospital, Hefei, Anhui, China. 5 Department of Science and Education, Shangluo Central Hospital, Shangluo, China. 6 Department of Nuclear Medicine, Xuanwu Hospital, Beijing, China. 7 GE Healthcare, MR Research, Beijing, China. 8 Department of Neurology, China-Japan Friendship Hospital, Beijing, China. Email: Lei Du Zifang Zhao Ailing Cui Yijiang Zhu Lu Zhang Jing Liu Sumin Shi Chao Fu Xiaowei Han Wenwen Gao Tianbin Song Lizhi Xie Lei Wang Shilong Sun Runcai Guo Guolin Ma
[email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] Page 1 of 25
ACS Paragon Plus Environment
ACS Chemical Neuroscience 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60
42
ABSTRACT
43
The excessive accumulation of iron in deep gray structures is an important
44
pathological characteristic in patients with Alzheimer's disease (AD). Quantitative
45
susceptibility mapping (QSM) is more specific than other imaging-based iron
46
measurements modalities and allows non-invasively assessment of tissue magnetic
47
susceptibility, which has been shown to correlate well to the brain iron levels. This
48
study aimed to investigate the correlations between the magnetic susceptibility values
49
of deep gray matter nuclei and the cognitive functions assessed by mini-mental state
50
examination (MMSE) and montreal cognitive assessment (MoCA) in patients with the
51
mild and moderate AD. Thirty subjects with the mild and moderate AD and 30 age-
52
and sex-matched healthy controls were scanned with a 3.0 T magnetic resonance
53
imaging (MRI) scanner. The magnetic susceptibilities of the regions of interest (ROIs),
54
including caudate nucleus (Cd), putamen (Pt), globus pallidus (Gp), thalamus (Th),
55
red nucleus (Rn), substantia nigra (Sn), and the dentate nucleus (Dn), were quantified
56
by QSM. We found that the susceptibility values of the bilateral Cd and Pt were
57
significantly higher in AD patients than the controls (P
