Indole-Derived Psammaplin A Analogues as Epigenetic Modulators

Oct 3, 2012 - ... of Medicinal Chemistry 2016 119, 45-69. Multitarget Drugs: an Epigenetic Epiphany. A. Ganesan. ChemMedChem 2016 11 (12), 1227-1241 ...

Pyrimidinylpiperdinyloxypyridone Analogues as GPR119 Modulators. Benjamin Blass*. Temple University School of Pharmacy, 3307 North Broad Street, ...

Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, Pennsylvania 19140, United States. ACS Med. Chem. Lett. , 2014, 5 (5), pp 458– ...

... 7473 Lusk Boulevard, San Diego, California 92121, United States, and Adjunct Associate Professor, Department of Pharmacology and Physiology, College of ...

Oct 3, 2008 - A series of 21 analogues of tetrahydrolipstatin (THL, 1) were ... IC50 values lower than 50 nM (IC50 of THL ) 1 µM) and were between 23- and ...

Oct 3, 2008 - Praveen K. Singh , Rachel Markwick , Leanne Lu , Fiona V. Howell , Gareth Williams , and Patrick Doherty. Biochemistry 2016 55 (19), 2713- ...

Oct 3, 2008 - IC50 values lower than 50 nM (IC50 of THL ) 1 µM) and were between 23- and 375-fold selective vs 2-AG hydrolysis by monoacylglycerol ...

Jun 20, 2013 - Assignee Company: University of Florida Research Foundation, USA. Disease Area: Nervous system diseases or disorders, inflammation, ...

Mar 19, 2015 - inducing stem cell differentiation involves epigenetic modifica- tion.1 Epigenetic modification refers to changes in gene activity and expression ...

We compare the ability of two structurally different classes of epigenetic modulators, namely, histone deacetylase (HDAC) inhibitors containing either a ...