Intramolecular Activation of a Ca2+-Dependent Protein Kinase Is

12102

Biochemistry 2000, 39, 12102

Corrections Intramolecular Activation of a Ca2+-Dependent Protein Kinase Is Disrupted by Insertions in the Tether That Connects the Calmodulin-like Domain to the Kinase, by Veronique Vitart, John Christodoulou, Jing-Feng Huang, Walter J. Chazin, and Jeffrey F. Harper*, Volume 39, Number 14, April 11, 2000, pages 4004-4011. Page 4008. In Table 3, the calcium-stimulated activity of KJM-41 (V-I444/AA) should be 1.80 (not 2.70), which makes it equivalent to 56% the activity of the wt (not 84%). This shows that the removal of large hydrophobic residues at the C-terminal end of the intramolecular binding site can disrupt intramolecular activation of a CDPK. BI005113+ 10.1021/bi005113+ Published on Web 09/07/2000