Subscriber access provided by UNIV OF NEBRASKA - LINCOLN
Article
Isoflavones in Chickpeas Inhibits Adipocyte Differentiation and Prevents Insulin Resistance in 3T3-L1 cells Yue Gao, Yang Yao, Ying-ying Zhu, and Guixing Ren J. Agric. Food Chem., Just Accepted Manuscript • DOI: 10.1021/acs.jafc.5b03957 • Publication Date (Web): 23 Oct 2015 Downloaded from http://pubs.acs.org on October 29, 2015
Just Accepted “Just Accepted” manuscripts have been peer-reviewed and accepted for publication. They are posted online prior to technical editing, formatting for publication and author proofing. The American Chemical Society provides “Just Accepted” as a free service to the research community to expedite the dissemination of scientific material as soon as possible after acceptance. “Just Accepted” manuscripts appear in full in PDF format accompanied by an HTML abstract. “Just Accepted” manuscripts have been fully peer reviewed, but should not be considered the official version of record. They are accessible to all readers and citable by the Digital Object Identifier (DOI®). “Just Accepted” is an optional service offered to authors. Therefore, the “Just Accepted” Web site may not include all articles that will be published in the journal. After a manuscript is technically edited and formatted, it will be removed from the “Just Accepted” Web site and published as an ASAP article. Note that technical editing may introduce minor changes to the manuscript text and/or graphics which could affect content, and all legal disclaimers and ethical guidelines that apply to the journal pertain. ACS cannot be held responsible for errors or consequences arising from the use of information contained in these “Just Accepted” manuscripts.
Journal of Agricultural and Food Chemistry is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Published by American Chemical Society. Copyright © American Chemical Society. However, no copyright claim is made to original U.S. Government works, or works produced by employees of any Commonwealth realm Crown government in the course of their duties.
Page 1 of 35
Journal of Agricultural and Food Chemistry
224x171mm (96 x 96 DPI)
ACS Paragon Plus Environment
Journal of Agricultural and Food Chemistry
1
Isoflavones in Chickpeas Inhibits Adipocyte Differentiation and Prevents Insulin
2
Resistance in 3T3-L1 cells
3
Yue Gao,†,§, Yang Yao,†,‡, Yinging Zhu,†,ǁ, and Guixing Ren*,‡
4 5 6
‡
7
South Xueyuan Road, Haidian, Beijing 100081, People’s Republic of China
8
§
9
Jinan, Shandong 250353, People’s Republic of China
Institute of Crop Science, Chinese Academy of Agricultural Sciences (CAAS), 80
Qilu University of Technology, 3501 Daxue Road, Western University Science Park,
10
ǁAnimal
11
Déportés 2, B-5030 Gembloux, Belgium
Science Unit, Gembloux Agro-Bio Tech, University of Liège, Passage des
12 13 14 15 16 17 18 19 20 21
*E-mail:
[email protected].
22
†
Yue Gao, Yang Yao and Yingying Zhu contributed equally to this work 1
ACS Paragon Plus Environment
Page 2 of 35
Page 3 of 35
Journal of Agricultural and Food Chemistry
23
ABSTRACT
24
Diabetes mellitus is a metabolic disease characterized by hyperglycemia arising
25
out of defects in insulin secretion. This study investigated the effects of isoflavones in
26
chickpea sprouts germinated in light (IGL) and isoflavones in chickpea seeds (ICS) on
27
insulin resistance through their role in suppression of 3T3-L1 adipocyte
28
differentiation. Results showed that IGL and ICS inhibit the differentiation of 3T3-L1
29
pre-adipocytes induced by differentiation medium in a dose-dependent manner, the
30
suppressive effect of IGL was stronger (p
