Isolation of Discrete Nanoparticle− DNA Conjugates for Plasmonic

Mar 11, 2008 - Chiroplasmonic Assemblies of Gold Nanoparticles for Ultrasensitive Detection of 8-Hydroxy-2′-deoxyguanosine in Human Serum Sample...
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Isolation of Discrete Nanoparticle-DNA Conjugates for Plasmonic Applications

2008 Vol. 8, No. 4 1202-1206

Shelley A. Claridge, Huiyang W. Liang, S. Roger Basu, Jean M. J. Fréchet,* and A. Paul Alivisatos* Department of Chemistry, Berkeley, California 94720, and E. O. Lawrence Berkeley National Laboratory, DiVision of Materials Science, Berkeley, California 94720 Received January 21, 2008; Revised Manuscript Received February 16, 2008

ABSTRACT Discrete DNA-gold nanoparticle conjugates with DNA lengths as short as 15 bases for both 5 and 20 nm gold particles have been purified by anion-exchange HPLC. Conjugates comprising short DNA (