Journal of Medicinal Chemistry - ACS Publications - American

Tufts University School of Medicine. PHILIP S. PORTOGHESE ... University of Colorado School of Medicine ... this journal. Business and Subscription In...
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Journal of Medicinal Chemistry Published by the American Chemical Society at 20th and Northampton Sts., Easton, Pennsylvania EDITOR ALFRED BURGER Department of Chemistry, University of Virginia, Charlottesville, Virginia

22901

ASSISTANT EDITOR MANFRED E. WOLFF University of California (San Francisco)

EDITORIAL ADVISORY BOARD BARRY M. BLOOM Chas. Pfizer Medical Research Laboratories

SEYMOUR EHRENPREIS New York Medical College

P H I L I P S. PORTOGHESE University of Minnesota

CHESTER J. CAVALLITO Ayerst Laboratories

GERTRUDE B. ELION The Wellcome Research Laboratories

WILLIAM P. PURCELL University of Tennessee

RAYMOND E. COUNSELL University of Michigan

RICHARD V. HEINZELMAN The Upjohn Company

HOWARD J. SCHAEFFER Burroughs Wellcome U.S.A., Inc.

C R. CREVELING National Institutes of Health

HENRY G. MAUTNER Tufts University School of Medicine

JOHN M. STEWART University of Colorado School of Medicine

EX-OFFICIO:

ARTHUR A . PATCHETT, Merck Sharp and Dohme Research Laboratories (Secretary, Division of Medicinal Chemistry)

MANAGER, EDITORIAL PRODUCTION:

CHARLES R. BERTSCH

Editorial Production Office, American Chemical Society, 20th and Northampton Sts., Easton, Pennsylvania

Society, 1155 Sixteenth St., N.W., Washington, D. C. 20036. Changes of address for this journal must be received four weeks before the first issue is to go to the new address. Please include both old and new addresses, with ZIP codes, and a mailing label from a copy of one of your ACS publications.

© Copyright, 1970, by the American Chemical Society. Published bimonthly by the American Chemical Society at 20th and Northampton Sts., Easton, Pennsylvania 18042. Second-class postage paid at Easton, Pennsylvania. Manuscripts for publication and books for review in this journal should be sent to the Editor, ALFRED BURGER, Department of Chemistry, University of Virginia, Charlottesville, Virginia 22901. Correspondence regarding accepted papers, proofs, and reprints should be directed to Editorial Production Office, American Chemical Society, 20th and Northampton Sts., Easton, Pennsylvania 18042. Manager: CHARLES R. BERTSCH. Senior Production Editor: MARIANNE C. BROGAN.

Subscriptions should be renewed promptly, to avoid a break in your series. Claims for missing numbers will not be allowed (1) if received more than sixty days from date of issue plus time normally required for postal delivery of journal and claim, (2) if loss was due to failure of notice of change in address to be received before the date specified in the previous paragraph, or (3) if the reason for the claim is "missing from files."

Editorial Assistant: MARGARET A. SULLIVAN.

Advertising Office: Century Communications Corporation, 142 East Ave., Norwalk, Conn. 06851. The American Chemical Society and the Editors of the Journal of Medicinal Chemistry assume no responsibility for the statements and opinions advanced by contributors to this journal.

Subscription rates for 1970: to members, $10.00 per year; to nonmembers, $20.00 per year. Postage to Canada and countries in the Pan-American Union, $3.00; all other countries, $3.50. Single copies: current year $5.00. Rates for back issues from 1962 to date are available from the Special Issues Sales Department, 1155 Sixteenth St., N.W., Washington, D. C. 20036. This publication and the other ACS periodical publications are now available on microfilm. For information write to: MICROFILM, Special Issues Sales Department, 1155 Sixteenth St., N.W., Washington, D. C. 20036.

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JOSEPH H. KUNEY Director of Business Operations Director of Publications Research

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DAVID E. GUSHEE Publication Manager, Journals