Vol. 8, NO.4 , July-August 1975
Kinetics of Helix-Coil Transition in Polypeptides 531
Kinetics of Helix-Coil Transition in All Sizes of Polypeptides Teresa Ree Chay*l*and Charles L. Stevenslb Department of Biophysics a n d Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260. Received J u l y 25, 1974
ABSTRACT: The relaxation behavior of the helix-coil transition has been investigated for all sizes of polypeptides. Unlike previously reported results, regardless of the size of polypeptides, the first-order kinetics plays a principal role in the relaxation process when a helical state is relaxed to a half-coiled state [Le., s(f) N 1, where s(f) is the helix stability parameter a t the final state]. On the other hand, when a helical state is relaxed to a coiled state [Le., s(f) > 1 and s(f)
