774 Journal of Medicinal Chemistrq, 1979, Vol 22, h'o 7
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Structural Requirements in Positions 1, 2, 3, and 6 of the Luteinizing Hormone-Releasing Hormone (LH-RH) for Antiovulatory Activity' John Humphries, Yieh-Ping Wan, Tadeusz Wasiak,* Karl Folkers.* Institute f o r Biomedical Research, C n i i w s i t q of Texac at Austin, Austin. l'exa\ 78712
and Cyril Y. Bowers Tulane Cniuersit3, N e u Orleans, Louisiana 70112. Receiied Januar) 22, 1979 Sixteen analogues of the luteinizing hormone-releasing hormone (LH-RH)were synthesized by the solid-phase method. In new and surprising relationships, it was found that the substitution of D-Trp into position 3 of [u-
