ORGANIC LETTERS
LiCl-Mediated Preparation of Highly Functionalized Benzylic Zinc Chlorides
2008 Vol. 10, No. 6 1107-1110
Albrecht Metzger, Matthias A. Schade, and Paul Knochel* Department Chemie und Biochemie, Ludwig-Maximilians-UniVersita¨t, Butenandtstrasse 5-13, 81377, Mu¨nchen, Germany
[email protected] Received December 20, 2007
ABSTRACT
In the presence of zinc dust (1.5−2.0 equiv) and LiCl (1.5−2.0 equiv), various benzylic chlorides bearing functional groups (iodide, cyanide, ester, ketone) are smoothly converted at 25 °C to the corresponding zinc reagents without homo-coupling (
