EDITOR-IN-CHIEF
editor ial
William S. Hancock Barnett Institute and Department of Chemistry Northeastern University 360 Huntington Avenue 341 Mugar Bldg. Boston, MA 02115 617-373-4881; Fax: 617-373-2855
[email protected] ASSOCIATE EDITORS
Linking Proteins to Disease Processes
Joshua LaBaer Harvard Medical School
György Marko-Varga AstraZeneca and Lund University
EDITORIAL ADVISORY BOARD
Ruedi H. Aebersold Institute for Systems Biology
Leigh Anderson Plasma Proteome Institute
Ettore Appella National Cancer Institute
Rolf Apweiler European Bioinformatics Institute
Ronald Beavis University of Chicago
Walter Blackstock Cellzome
Brian Chait The Rockefeller University
Patrick L. Coleman 3M
Christine Colvis National Institutes of Health
Catherine Fenselau University of Maryland
Daniel Figeys MDS Proteomics
Sam Hanash University of Michigan
Stanley Hefta Bristol-Myers Squibb
Donald F. Hunt University of Virginia
Barry L. Karger
e are very pleased to present this special thematic issue of the Journal of Proteome Research, which is dedicated to the important topic of proteomics and disease. Over the past few years, we have watched with special interest as the leading technologies have been applied to studies that seek to discover the identities and roles of proteins in life’s biological processes. There is a natural interaction today between academic, industrial, biotech, and pharmaceutical colleagues who share an interest in developing our understanding of the protein components within pathways, systems, and organisms. We are a community interested in providing detailed knowledge about the structure–function–expression interrelationships that support and determine cellular activity. We have a strong link between technology and biology that gives us an unprecedented opportunity to understand the natural history of disease processes. Some time ago, the two of us joined our two groups together. György’s the protein chemist, skilled in technology applications such as microscale separation platforms and MS identity analysis. Tom is the pathobiologist with one eye down the business end of a microscope and the other on in vivo experimental models. Then, about a year ago, we had the idea to compose this volume. We thought that the time was especially right for assembling the critical thinking around a central theme linking proteins to disease processes. From pathways to biomarkers. From organelles to organisms. We contacted many leading laboratories and a number of our colleagues and friends and asked for their contributions. The result is this volume. We thank the American Chemical Society for sponsoring this dedicated issue. We hope that this collection of papers will serve as a platform for discussion and debate. We intended the individual papers to serve as primers for students and professors, for physicists and Deans of Medicine, and for all of us within the proteomics community. Finally, we wish to acknowledge and express our sincere gratitude to the authors and contributors of the papers that follow. You answered our call, and we are truly grateful.
W
Northeastern University
Daniel C. Liebler Vanderbilt University School of Medicine
Lance Liotta National Cancer Institute
Matthias Mann University of Southern Denmark
Stephen A. Martin Applied Biosystems
Jeremy Nicholson Imperial College of London
Gilbert S. Omenn University of Michigan
Emanuel Petricoin Food and Drug Administration
J. Michael Ramsey Oak Ridge National Laboratory
Pier Giorgio Righetti University of Verona
John T. Stults Biospect
Peter Wagner Zyomyx
Keith Williams Proteome Systems
Qi-Chang Xia Shanghai Institute of Biochemistry
John R. Yates, III The Scripps Research Institute
© 2004 American Chemical Society
Journal of Proteome Research • Vol. 3, No. 2, 2004
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