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Article Cite This: ACS Omega 2018, 3, 8648−8654
http://pubs.acs.org/journal/acsodf
Local Domain Size in Single-Chain Polymer Nanoparticles José A. Pomposo,*,†,‡,§ Angel J. Moreno,†,∥ Arantxa Arbe,† and Juan Colmenero†,‡,∥ †
ACS Omega 2018.3:8648-8654. Downloaded from pubs.acs.org by 191.101.55.73 on 08/15/18. For personal use only.
Centro de Física de Materiales (CSIC, UPV/EHU) and Materials Physics Center MPC, Paseo Manuel de Lardizabal 5, E-20018 San Sebastián, Spain ‡ Departamento de Física de Materiales, Universidad del País Vasco (UPV/EHU), Apartado 1072, E-20800 San Sebastián, Spain § IKERBASQUEBasque Foundation for Science, María Díaz de Haro 3, E-48013 Bilbao, Spain ∥ Donostia International Physics Center (DIPC), Paseo Manuel de Lardizabal 4, E-20018 San Sebastián, Spain ABSTRACT: Single-chain polymer nanoparticles (SCNPs) obtained through chain collapse via intramolecular crosslinking are attracting significant interest for nanomedicine and biomimetic catalysis applications, among other fields. This interest arises from the possibility to bind active species (e.g., drugs and catalysts)either temporally or permanentlyto the SCNP local pockets formed upon chain collapse. However, direct quantification of the size and number of such local domains in solutioneven if highly desirableis currently highly demanding from an experimental point of view because of the small size involved (
