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Unifying the Field of Conjugation Chemistry...

Bioconjugate Chemistry

The Classic

Editor: Claude F. Meares, University of California, Davis

NUCLEOSIL® spherically shaped silica gel for HPLC and GPC Enantiomer separation of mecoprop

Centralized Access is Here! Featuring highly technical, primary literature in biomedically related R&D, Bioconjugate Chemistry centralizes information previously published in some 200 different scholarly journals. It brings together—in one source—research forming the core of breakthroughs in biotechnology from universities, research institutes, biomedical firms, drug companies, and chemical laboratories. Specifically, Bioconjugate Chemistry addresses the joining of two different molecular functions by chemical or biological means. No other journal has this unique, topical focus: Conjugation of... antibodies (and their fragments) nucleic acids and their analogues (a-anomers, phosphonates,...) liposomal components other biologically active molecules (receptor-binding proteins, hormones, peptides,. ..) with each other or with any molecular groups that add useful properties... drugs, radionuclides, toxins, fluorophores, photoprobes, inhibitors, enzymes, haptens, ligands, etc.

Column: Eluent: Flow rate: Pressure: Detection:

ET 200/8/4 NUCLEODEX o-PM methanol/50 mM NaH 2 P0 4 , pH 3.0 (70 : 30) 0.7 m l / m i n 170 bar UV, 230 η m

NUCLEOSIL® packings for analytical and preparative separations

In bimonthly issues you'll explore the chemical aspects of conjugate preparation and characterization, including: • In vivo applications of conjugate methodology; • Molecular biological aspects of antibodies, genetically engineered fragments, and other immunochemicals; • The relationships between conjugation chemistry and the biological properties of conjugates.

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MACHEREY-NAGEL GmbH & Co. KG • P.O. Box 101352 · D-52313 Diiren Germany · Tel. (0 24 21 ) 6 9 8 - 0 · Telex 8 33 893 mana d • Telefax (0 24 21 ) 6 20 54

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506 A

Analytical

Chemistry,

Vol. 66, No. 9, May 1, 1994

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