Made in the
USA A Perfect Fit. AMRI and Organichem Have Joined! Albany Molecular Research, Inc. offers a full range of drug discovery services and high quality cGMP and non-cGMP manufacturing of small molecule development candidates, intermediates and APIs. With accessible locations throughout the U.S. that make doing business with us practical and convenient. Whether you need a few hundred grams of a compound for preclinical development, or a few metric tons for a product launch, AMRFs and Organichem's seasoned employees offer superior quality and efficiency. Led by a management team with over 250 cumulative years of pharmaceutical industry experience. All supported by accessible, state-of-the-art facilities near Seattle, Chicago, and in upstate New York. Contact us today for more information, and start reaping the convenience and excellence of an AMRI partnership.
I b ^ f t ' Albany Molecular Research. Inc.®
21 Corporate Circle, P.O. Box 15098 • Albany, NY 12212-5098 Phone: 518-464-0279 • Fax: 518-464-0289 • www.albmolecular.com
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P r o j e c t g o a l : To prepare 16 kg of an intermediate in six weeks. D e t a i l s : The synthesis of the intermediate required three steps—a hydride reduction, hydrogenation of an aromatic ring, and tosylation of an alcohol. Some development work was needed. O u t c o m e : After conducting some process research, AMRI's chemical development team delivered the following results: • Modified work up of the first step, making it twice as productive. • Changed the catalyst in the hydrogenation, saving $14,000 and increasing the yield from 85% to 99%. • Increased the concentration of the third step, improving the productivity by 50%. • Delivered the product to the customer two weeks early.
Call AMRI today to learn how we can help your drug development efforts. 21 Corporate Circle, P.O. Box 15098 Albany, NY 12212-5098 Phone:518-464-0279 • Fax:518-464-0289
[email protected] • www.albmolecular.com
F o l l o w - u p : The customer returned to AMRI with a request to synthesize 85 kg of the same compound. The starting material was ordered by the customer from an overseas supplier with an anticipated delivery that would leave eight weeks for the synthesis. The starting material arrived four weeks later than promised. Under a tight time frame, AMRI development scientists made improvements to the process that allowed this synthesis to be carried out at a price per kg that was 46% lower than the initial preparation. In addition, AMRI scientists delivered the desired 85 kg in six weeks, preventing a delay in the customer's program.
