Letter pubs.acs.org/NanoLett
Magnetic Force Nanoprobe for Direct Observation of Audio Frequency Tonotopy of Hair Cells Ji-wook Kim,†,‡,§ Jae-Hyun Lee,†,‡,§ Ji-Hyun Ma,∥,# Eunna Chung,†,‡,§ Hongsuh Choi,†,‡,§ Jinwoong Bok,∥,⊥,# and Jinwoo Cheon*,†,‡,§ †
Center for Nanomedicine, Institute for Basic Science (IBS), Seoul 03722, Republic of Korea Yonsei-IBS Institute, Yonsei University, Seoul 03722, Republic of Korea § Department of Chemistry, Yonsei University, Seoul 03722, Republic of Korea ∥ Department of Anatomy, ⊥Department of Otorhinolaryngology, and #BK21 PLUS project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea ‡
S Supporting Information *
ABSTRACT: Sound perception via mechano-sensation is a remarkably sensitive and fast transmission process, converting sound as a mechanical input to neural signals in a living organism. Although knowledge of auditory hair cell functions has advanced over the past decades, challenges remain in understanding their biomechanics, partly because of their biophysical complexity and the lack of appropriate probing tools. Most current studies of hair cells have been conducted in a relatively low-frequency range (
