Manipulation of proteins on mica by atomic force microscopy

Orientation of a Monoclonal Antibody Adsorbed at the Solid/Solution Interface: A Combined Study Using Atomic Force Microscopy and Neutron Reflectivity...
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Langmuir 1992,8, 68-13

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Manipulation of Proteins on Mica by Atomic Force Microscopy A. S. Lea,t A. Pungor,t V. Hlady,tJ J. D. Andrade,*gtJ. N. Herron,s and E. W. Voss, Jr.11 Departments of Bioengineering and of Pharmaceutics, University of Utah, Salt Lake City, Utah 84112, and Department of Microbiology, University of Illinois, Urbana, Illinois 61801 Received March 1, 1991.I n Final Form: June 25, 1991 The atomic force microscope was used to image adsorption of a monoclonal IgM on mica in real time. Under the smallest possible force we could achieve (