Technical Notes Anal. Chem. 1996, 68, 708-711
Gas Chromatographic/Mass Spectrometric Calibration Bias J. R. Troost*
Southern Petroleum Laboratories, Lafayette, Louisiana 70583 E. Y. Olavesen University of New Orleans, New Orleans, Louisiana 70148
A systematic bias has been observed in the calibration of a number of commercial quadrupole gas chromatographic/ mass spectrometric (GC/MS) instruments using conventional internal standard quantification techniques. Response factors between deuterated polynuclear aromatic hydrocarbons and selected analytes are presented for a series of calibration curves generated according to commonly used capillary column semivolatile organic environmental analysis methods. Examples of pronounced response factor trends are given over calibration ranges of
