Mass Spectrometry - American Chemical

separation, site-specific proteolysis of fusion proteins, and the use ofappliedelectric fields for downstream processing. Michael R. Ladisch, Editor, ...
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Liquid Chromatography/ Mass Spectrometry Applications in Agricultural, Pharmaceutical, and Environmental Chemistry

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ne of the most exciting aspects of LC/MS is its versatility and the potential it of­ fers for many new applications. This im­ portant volume provides an in-depth look at this analytical process and describes the in­ strumentation now available or under development. This book discusses recent innovations such as the use of thermospray and particle beam interfaces that have made LC/MS methods much more compatible for the analysis of pes­ ticides, pharmaceuticals, and pollutants. The first section in this 18-chapter volume describes applications of LC/MS to the analysis of polar or thermally labile agricultural chemi­ cals including chlorinated herbicides and pesti­ cide residues. The second section focuses on applications in the analysis of intractable phar­ maceuticals and their metabolites. The last section offers a better understand­ ing of LC/MS methods used in environmental analysis. Included are examples of the use of LC/MS for the analysis of target and nontarget environmental pollutants, as well as their me­ tabolites and conjugates. Mark A. Brown, Editor, California Department of Health Services Developed from a symposium sponsored by the Divi­ sion of Agrochemicals of the American Chemical Society ACS Symposium Series No. 420 312 pages (1990) Clothbound ISBN 0-8412-1740-8 LC 89-18611 $64.95 0 · R · D · Ε • R

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Protein Purification From Molecular Mechanisms to Large-Scale Processes

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his timely new volume gives real exam­ ples of how separation techniques are used in industry with recombinant pro­ teins, and emphasizes which techniques might be more useful than others in real world applications. With contributions from leading experts in the field, this volume covers both academic and industrial interests. It shows how series can be applied to developing strategies and emphasizes appropriate approaches for diffi­ cult protein separation problems. New separation techniques are evaluated for their practicality in connection with recom­ binant proteins on an industrial scale. These include: • adsorption • extraction • liquid chromatography • centrifugation • electrophoresis Some of the specific topics discussed are adsorptive separations, mechanisms of protein retention in hydrophobic interaction chroma­ tography, radial-flow affinity chromatography for trypsin purification, metal-affinity protein separation, site-specific proteolysis of fusion proteins, and the use of applied electric fields for downstream processing. Michael R. Ladisch, Editor, Purdue University Richard C. Willson, Editor. University of Houston

Claisse Fluxes (Borates and Phosphates)

perspective on analysis and better results. The CLAISSE FLUXES have exceptional qualities due to their PURITY and COARSE texture.

Claisse Fluxes are Tip-Top. FEATURES • f r e e - f l o w i n g crystals • l o w surface area • high d e n s i t y • fused, not mixed • popular and special compositions CONSEQUENT ADVANTAGES • no loss f r o m static e l e c t r i c i t y • no loss b y splattering or f o a m i n g

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Chih-duen C. Painton, Editor. Mallinckrodt Medical, Inc. Stuart E. Builder, Editor, Genetech, Inc. Developed from a symposium sponsored by the Division of Biochemical Technology of the American Chemical Society ACS Symposium Series No. 427 280 pages (1990) Clothbound ISBN 0-8412-1790-4 LC 90-35551 $64.95 0 · R · D · Ε · R

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American Chemical Society Distribution Office, Dept 64 1155 Sixteenth St.. N.W. Washington, DC 20036 or CALL TOLL FREE

American Chemical Society Distribution Office, Dept. 71 1155 Sixteenth St., N.W. Washington, DC 20036 or CALL TOLL FREE

800-227-5558

800-227-5558

(in Washington. D.C. 872-4363) and use your credit card!

(in Washington, D.C. 872-4363) and use your credit card!

For world-wide sales, address of local agents and service information please call or write to: corporation scientifique claisse inc.

2522, chemin Sainte-Foy Sainte-Foy (Québec) Canada G1V 1T5 Tel: (418) 656-6453 Fax: (418) 656-1169 Telex: 051-31731

The First and Finest in Fusion.

CIRCLE 22 ON READER SERVICE CARD ANALYTICAL CHEMISTRY, VOL. 63, NO. 13, JULY 1, 1991 · 685 A