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A metamaterial combining electric- and magnetic- dipolebased configurations for unique dual-band signal enhancement in ultra-high field magnetic resonance imaging Rita Schmidt, and Andrew Webb ACS Appl. Mater. Interfaces, Just Accepted Manuscript • DOI: 10.1021/acsami.7b06949 • Publication Date (Web): 13 Sep 2017 Downloaded from http://pubs.acs.org on September 14, 2017
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ACS Applied Materials & Interfaces
A metamaterial combining electric- and magneticdipole-based configurations for unique dual-band signal enhancement in ultra-high field magnetic resonance imaging Rita Schmidt1,2* and Andrew Webb1 1 Department of Radiology, Leiden University Medical Center, Leiden, Netherlands 2 Visiting Scientist in Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel E-mail:
[email protected] Keywords: metamaterial, dual-band, magnetic resonance imaging, ultra-high field, in-vivo Abstract Magnetic resonance imaging and spectroscopy (MRI and MRS) are both widely used techniques in medical diagnostics and research. One of the major thrusts in recent years has been the introduction of ultra-high field magnets in order to boost the sensitivity. Several MRI studies have examined further potential improvements in sensitivity using metamaterials, focusing on single frequency applications. However, metamaterials have yet to reach a level which is practical for routine MRI use. In this work, we explore a new metamaterial implementation for MRI, a dualnuclei resonant structure, which can be used for both proton and heteronuclear magnetic resonance. Our approach combines two configurations, one based on a set of electric dipoles for the low frequency band, and the second based on a set of magnetic dipoles for the high frequency band. We focus on the implementation of a dual-nuclei metamaterial for phosphorous and proton imaging and spectroscopy at an ultra-high field strength of 7 Tesla. In vivo scans using this flexible and compact structure show that it locally enhances both the phosphorous and proton transmit and receive sensitivities.
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ACS Applied Materials & Interfaces
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Introduction Magnetic resonance imaging (MRI) is one of the most important modalities for clinical disease diagnosis, as well as playing a key role in fundamental pre-clinical research. Its major advantages include non-ionizing radiation, lack of penetration effects, ability to acquire fully isotropic three-dimensional data, and the ability to produce a variety of image contrasts between tissues using different data acquisition parameters. The major disadvantage of MRI arises from its low sensitivity, which is a result of the small energy difference between energy levels. Alternative non-inductive detection methods have been explored at very low magnetic fields (
