MIDA Boronate Building Blocks: Towards a general platform for small molecule synthesis Live Webinar: March 23, 2010 2:00 p.m. EST • 1:00 p.m. CST • 12:00 p.m. GMT • 11:00 a.m. PST Broadcast live at the ACS Spring National Meeting Room 114N Overview: In an idealized form of the building block approach for small molecule synthesis, off-the-shelf subunits having all of the required functional groups preinstalled in the correct oxidation states and with the desired stereochemical relationships are brought together via the recursive application of one stereospecific reaction. Analogous to peptide coupling, this strategy aims to maximize the simplicity, efficiency, and flexibility with which small molecules can be made in the laboratory. MIDA boronates represent a powerful platform of building blocks with the potential to broadly enable this type of synthesis. The webinar will discuss the many physical and chemical features of MIDA boronates that underlie their widespread utility, including:
Your host for this webinar will be: Martin D. Burke, Ph.D., M.D. Assistant Professor of Chemistry Early Career Scientist of the Howard Hughes Medical Institute University of Illinois at UrbanaChampaign
Moderator: A. Maureen Rouhi, Ph.D. Deputy Editor-in-Chief C&EN
• Ease of preparation, purification, and storage and minimized environmental impact Reversibly attenuated boronic acid reactivity that enables small molecule synthesis via iterative cross-coupling
Who Should Attend?
Capacity for slow-release cross-coupling that transforms even notoriously unstable 2-heterocyclic, vinyl, and cyclopropyl subunits into air-stable and highly effective cross-coupling partners
• medicinal chemists
Compatibility with a wide range of common reaction conditions which enables the multistep synthesis of structurally complex boronic acids from simple B-containing starting materials Sponsored by:
• synthetic organic chemists • process chemists • leaders in the pharmaceutical industry • instructors of organic chemistry courses
Hosted by:
For more information on MIDA boronates, please visit www.aldrich.com/mida
Register FREE at http://cenwebinars.stream57.com/midaboronate/
