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Sep 29, 2017 - Bioavailability in Rice Based on a Mouse Bioassay ... Soil and Water Science Department, University of Florida, Gainesville, Florida 32...
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Mineral dietary supplements to decrease cadmium relative bioavailability in rice based on a mouse bioassay Di Zhao, Albert L. Juhasz, Jun Luo, Lei Huang, Xiaosan Luo, Hong-bo Li, and Lena Q. Ma Environ. Sci. Technol., Just Accepted Manuscript • DOI: 10.1021/acs.est.7b02993 • Publication Date (Web): 29 Sep 2017 Downloaded from http://pubs.acs.org on September 29, 2017

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Environmental Science & Technology

Mineral dietary supplements to decrease cadmium relative bioavailability in rice based on a mouse bioassay Di Zhao,† Albert L. Juhasz,‡ Jun Luo,† Lei Huang,† Xiao-San Luo,§ Hong-Bo Li,*,† and Lena Q. Ma†,ǁ



State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment,

Nanjing University, Nanjing 210023, People’s Republic of China ‡

Future Industries Institute, University of South Australia, Mawson Lakes, South Australia

5095, Australia §

Jiangsu Key Laboratory of Agricultural Meteorology, International Center for Ecology,

Meteorology, and Environment, Nanjing University of Information Science & Technology, Nanjing 210044, People’s Republic of China ǁ

Soil and Water Science Department, University of Florida, Gainesville, Florida 32611,

United States

*

Corresponding author, State Key Laboratory of Pollution Control and Resource Reuse,

School of the Environment, Nanjing University, Nanjing 210023, China; Tel./fax: +86 025 8968 0637, E-mails: [email protected]; [email protected]

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Environmental Science & Technology

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ABSTRACT: To determine the effectiveness of mineral dietary supplements to modulate

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cadmium (Cd) exposure, an in vivo mouse bioassay was conducted to determine Cd relative

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bioavailability (RBA) in a Cd-contaminated rice (0.80 mg Cd kg–1) with and without Zn, Fe,

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or Ca supplements as nitrate or chloride salts. Without mineral supplements, Cd-RBA was

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43±5.3% based on average Cd accumulation in the liver plus kidneys as the endpoint. Among

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Ca(NO3)2, Zn(NO3)2, and Fe(NO3)2 supplements, 150–5000 mg kg–1 Ca was the most

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effective in reducing rice Cd-RBA by 31–80% to 8.5–29%, while 30–200 mg kg–1 Zn

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supplement was ineffective with Cd-RBA being at 33–57%. Low Fe at