Subscriber access provided by UNIV OF ESSEX
Article
Mineral dietary supplements to decrease cadmium relative bioavailability in rice based on a mouse bioassay Di Zhao, Albert L. Juhasz, Jun Luo, Lei Huang, Xiaosan Luo, Hong-bo Li, and Lena Q. Ma Environ. Sci. Technol., Just Accepted Manuscript • DOI: 10.1021/acs.est.7b02993 • Publication Date (Web): 29 Sep 2017 Downloaded from http://pubs.acs.org on September 29, 2017
Just Accepted “Just Accepted” manuscripts have been peer-reviewed and accepted for publication. They are posted online prior to technical editing, formatting for publication and author proofing. The American Chemical Society provides “Just Accepted” as a free service to the research community to expedite the dissemination of scientific material as soon as possible after acceptance. “Just Accepted” manuscripts appear in full in PDF format accompanied by an HTML abstract. “Just Accepted” manuscripts have been fully peer reviewed, but should not be considered the official version of record. They are accessible to all readers and citable by the Digital Object Identifier (DOI®). “Just Accepted” is an optional service offered to authors. Therefore, the “Just Accepted” Web site may not include all articles that will be published in the journal. After a manuscript is technically edited and formatted, it will be removed from the “Just Accepted” Web site and published as an ASAP article. Note that technical editing may introduce minor changes to the manuscript text and/or graphics which could affect content, and all legal disclaimers and ethical guidelines that apply to the journal pertain. ACS cannot be held responsible for errors or consequences arising from the use of information contained in these “Just Accepted” manuscripts.
Environmental Science & Technology is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Published by American Chemical Society. Copyright © American Chemical Society. However, no copyright claim is made to original U.S. Government works, or works produced by employees of any Commonwealth realm Crown government in the course of their duties.
Page 1 of 22
Environmental Science & Technology
Mineral dietary supplements to decrease cadmium relative bioavailability in rice based on a mouse bioassay Di Zhao,† Albert L. Juhasz,‡ Jun Luo,† Lei Huang,† Xiao-San Luo,§ Hong-Bo Li,*,† and Lena Q. Ma†,ǁ
†
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment,
Nanjing University, Nanjing 210023, People’s Republic of China ‡
Future Industries Institute, University of South Australia, Mawson Lakes, South Australia
5095, Australia §
Jiangsu Key Laboratory of Agricultural Meteorology, International Center for Ecology,
Meteorology, and Environment, Nanjing University of Information Science & Technology, Nanjing 210044, People’s Republic of China ǁ
Soil and Water Science Department, University of Florida, Gainesville, Florida 32611,
United States
*
Corresponding author, State Key Laboratory of Pollution Control and Resource Reuse,
School of the Environment, Nanjing University, Nanjing 210023, China; Tel./fax: +86 025 8968 0637, E-mails:
[email protected];
[email protected] 1
ACS Paragon Plus Environment
Environmental Science & Technology
TABLE OF CONTENT
2
ACS Paragon Plus Environment
Page 2 of 22
Page 3 of 22
Environmental Science & Technology
1
ABSTRACT: To determine the effectiveness of mineral dietary supplements to modulate
2
cadmium (Cd) exposure, an in vivo mouse bioassay was conducted to determine Cd relative
3
bioavailability (RBA) in a Cd-contaminated rice (0.80 mg Cd kg–1) with and without Zn, Fe,
4
or Ca supplements as nitrate or chloride salts. Without mineral supplements, Cd-RBA was
5
43±5.3% based on average Cd accumulation in the liver plus kidneys as the endpoint. Among
6
Ca(NO3)2, Zn(NO3)2, and Fe(NO3)2 supplements, 150–5000 mg kg–1 Ca was the most
7
effective in reducing rice Cd-RBA by 31–80% to 8.5–29%, while 30–200 mg kg–1 Zn
8
supplement was ineffective with Cd-RBA being at 33–57%. Low Fe at
