pubs.acs.org/Langmuir © 2010 American Chemical Society
Morphological Changes in Vesicles and Release of an Encapsulated Compound Triggered by a Photoresponsive Malachite Green Leuconitrile Derivative Ryoko M. Uda,† Eri Hiraishi,† Ryo Ohnishi,† Yoshio Nakahara,‡ and Keiichi Kimura*,‡ †
Department of Chemical Engineering, Nara National College of Technology, Yata 22, Yamato-koriyama, Nara 639-1080, Japan, and ‡Department of Applied Chemistry, Faculty of Systems Engineering, Wakayama University, Sakae-dani 930, Wakayama 640-8510, Japan Received November 4, 2009. Revised Manuscript Received March 7, 2010
Photoinduced morphological changes in phosphatidylcholine vesicles are triggered by a Malachite Green leuconitrile derivative dissolved in the lipidic membrane, and are observed at Malachite Green derivative/lipid ratios 40 mol %), which is in contrast to the composition of biomembranes. Thus, this amphiphile system is not ideal for use as a delivery system. The purpose of the current study was to characterize photoinduced morphological changes in phosphatidylcholine vesicles containing small amounts of a photoresponsive compound (
