Monograph pubs.acs.org/doi/book/10.1021/acsreagents
N-(1-Naphthyl)ethylenediamine Dihydrochloride Part 4, Monographs for Reagent Chemicals: General Descriptions, Specifications, and Tests eISBN: 9780841230460 Tom Tyner Chair, ACS Committee on Analytical Reagents James Francis Secretary, ACS Committee on Analytical Reagents
ABSTRACT This monograph for N-(1-Naphthyl)ethylenediamine Dihydrochloride provides, in addition to common physical constants, a general description including typical appearance, applications, and aqueous solubility. The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Sensitivity to Sulfanilamide, Solubility, and Water.
C12H14N2 • 2HCl
Formula Wt 259.18
CAS No. 1465-25-4
GENERAL DESCRIPTION Typical appearance . . . . . . . . . . . . . . . . . . . white solid; becoming pink on exposure to light Applications . . . . . . . . . . . . . . . . . . . . . . . . determination of sulfanilamide Aqueous solubility . . . . . . . . . . . . . . . . . . . . slightly soluble cold; readily soluble hot
SPECIFICATIONS Sensitivity to sulfanilamide . . . . . . . . . . . . . . Passes test Solubility. . . . . . . . . . . . . . . . . . . . . . . . . . Passes test Maximum Allowable Water (H2O) . . . . . . . . . . . . . . . . . . . . . . . . 5%
© 2017 American Chemical Society
A
DOI:10.1021/acsreagents.4236 ACS Reagent Chemicals, Part 4
ACS Reagent Chemicals
Monograph
pubs.acs.org/doi/book/10.1021/acsreagents
TESTS Sensitivity to Sulfanilamide Dissolve 0.1 g of sample in 100 mL of water to make the sample solution. Then, in two different Nessler tubes, dilute 1.0 and 2.5 mL of sulfanilamide solution (described below) with water to 100 mL. For the blank, omit the sulfanilamide from a third tube, and fill with water to 100 mL. To each tube, add 8 mL of trichloroacetic acid solution and 1 mL of sodium nitrite solution (both described below). After 3 min, add 1 mL of ammonium sulfamate solution (described below), then after 2 additional min, add 1 mL of sample solution. The tubes containing the sulfanilamide should turn pink to red, the higher concentration producing the deeper color.
For the Determination of Sensitivity to Sulfanilamide
S u l f a n i l a m i d e S o l u t i o n . Dissolve 0.02 g of sulfanilamide in 100 mL of water. Tr i c h l o r o a c e t i c A c i d S o l u t i o n . Dissolve 15 g of trichloroacetic acid in 100 mL of water. S o d i u m N i t r i t e S o l u t i o n . Dissolve 0.1 g of sodium nitrite in 100 mL of water. A m m o n i u m S u l f a m a t e S o l u t i o n . Dissolve 0.5 g of ammonium sulfamate in 100 mL of water.
Solubility A solution of 1 g in 50 mL of water is clear, and dissolution is complete.
Water [Part 2: Titrimetric Methods; Water by the Karl Fischer Method; Volumetric Procedure; Volumetric Procedure for Samples Using Karl Fischer Reagent, Method 1]. Use 3.0 g of the sample.
© 2017 American Chemical Society
B
DOI:10.1021/acsreagents.4236 ACS Reagent Chemicals, Part 4
