Langmuir 2005, 21, 4257-4261
4257
Nanoscale-Controlled Spacing Provides DNA Microarrays with the SNP Discrimination Efficiency in Solution Phase Bong Jin Hong, Soon Jin Oh, Tae One Youn, Sung Hong Kwon, and Joon Won Park* Center for Integrated Molecular Systems, Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Korea Received December 13, 2004. In Final Form: March 21, 2005 We have prepared solid substrates modified with a cone-shaped dendron that generates mesospacing (3.2 nm on average) on the surface. This nanoscale-controlled surface provided an ideal DNA microarray in which each probe DNA strand was given ample space for the incoming target DNA, resulting in selectivity as high as that in solution (100:
