ARTICLE pubs.acs.org/IECR
Natural Nontoxic Solvents for Recovery of Picolinic Acid by Reactive Extraction Mangesh D. Waghmare,† Kailas L. Wasewar,*,‡ Shriram S. Sonawane,‡ and Diwakar Z. Shende‡ † ‡
Department of Chemical Engineering, Priyadarshini Institute of Engineering and Technology, Nagpur, 440019, India Department of Chemical Engineering, Visvesvaraya National Institute of Technology, Nagpur, 440010, India ABSTRACT: Pyridine carboxylic acids and their derivatives are attracting considerable attention for their presence in many natural products. 2-Pyridinecarboxylic acid, also known as picolinic acid is widely used in the pharmaceutical industries. Compared to chemical methods, enzymatic oxidation of 3-hydroxyanthranillic acid is an advantageous alternative for the production of picolinic acid. Reactive extraction is a promising method to recover carboxylic acid but suffers from toxicity problems of the diluent and extractant employed, therefore there is a need for a nontoxic extractant and diluent or a combination of less toxic extractants in a nontoxic diluent that can recover acid efficiently. The present paper focuses on the reactive extraction of picolinic acid using tri-n-butyl phosphate (TBP) in sunflower oil and castor oil. Results were presented in terms of distribution coefficients (0.0066 to 0.664 for sunflower oil and 0.0099 to 0.94 for castor oil), loading ratio (
