NELSON ANALYTICAL - ACS Publications - American Chemical Society

Jun 6, 2012 - NELSON ANALYTICAL. Anal. Chem. , 1982, 54 (12), pp 1306A–1306A. DOI: 10.1021/ac00249a779. Publication Date: October 1982...
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line disk storage for spectral libraries to aid in interpretation and for archi­ val storage. After benchmarking the interactive requirements, a dual Harris S200 sys­ tem with shared disk was installed in late 1977. The present system consists of a dual CPU Harris H-800 system with shared memory and 900 mega­ bytes of shared disk (Figure 4). Pres­ ently about 20 instruments are inter­ faced to the system. Users communi­ cate with the system via about 50 ter­ minals, including 13 Tektronix 4014 high-resolution graphics terminals with graphic input tablets. Four Ver-

satec printer/plotters located in labo­ ratories and a Calcomp plotter in the computer room provide hard-copy graphics output. Graphics program­ ming is done using a locally developed graphics subroutine package, based on the SIGGRAPH standard, which allows for device-independent graphics pro­ gramming, i.e., the same program can be written for any of the four different graphics devices currently on the sys­ tem. A set of sophisticated operating system extensions has been developed to support real-time data acquisition, including the digital input, analog input, and digital output functions

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NELSON ANALYTICAL

CIRCLE 155 ON READER SERVICE CARD 1306 A · ANALYTICAL CHEMISTRY, VOL. 54, NO. 12, OCTOBER 1982

used in most of the data acquisition activities. The system is currently supported by one systems programmer, one ap­ plications programmer, a resident Harris service engineer, and part-time efforts of two other people. There is no computer operator. For applica­ tion-specific programs, users usually do their own programming; for subsys­ tems that span across applications, programming support is provided. Roughly half of the plans that we have for the system are currently im­ plemented and operational. We have found the system to be very powerful and very reliable, with a high uptime. It performs all functions very well. Building on the success of our dual CPU Harris system, we have recently installed a Harris H-500 system, using the same software as the system dis­ cussed above, to support the needs of our Drug Metabolism Research Unit (about 50 research personnel), requir­ ing two additional programmers. This system, located in a different building, supports several dozen gas and liquid chromatographs, including many with automatic injection systems; several balances; and several liquid scintilla­ tion counters. The transfer of software between the dual H-800 system and the H-500 system was accomplished very smoothly. Since balances and chromatographs are supported on both systems, the savings on software have been great. We have also recently acquired a Harris H-300 system to support high-performance color graphics for use in drug design and molecular modeling activities. Again the same operating system is used. We estimate that the H-500 and the dual H-800 laboratory automation systems are equivalent to approxi­ mately 50 additional personnel in terms of additional output from the units supported. Using a central super-mini approach to laboratory au­ tomation has saved us much in shared peripheral devices, ease of program­ ming, cost of programming, and mainte­ nance support. We have a very power­ ful system, which each user looks to as his or her own. Major goals for the sys­ tem have been to provide good soft­ ware documentation and acceptable audit trails for data and software ma­ nipulation, as well as to provide sim­ ple and reliable backup. These are tasks difficult to handle adequately on distributed computers. The disadvan­ tages of the central approach are the high initial cost, the need to have a very capable systems programmer to make it work well, and the fact that all instrumentation is dependent upon a single computer system. In our experi­ ence, however, these disadvantages have been far outweighed by the ad­ vantages mentioned above.