Jul 1, 1991 - Joel D. Moore, Kevin T. Sprott, and Paul R. Hanson ... Gorini, Silvana D'Alessio, Michael Pieper, Harald Tschesche, and Paul A. Tucker...
May 1, 2005 - VLB and VCR differ only by the transformation, by ox- idation, of the indolic methyl of vindoline into a formyl group. The mechanism of action of ...
A series of new amino phosphonic acid derivatives of vinblastine (1, VLB) has been synthesizedand tested in vitro and in vivo for antitumor activity.
Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania ..... The synthesis of head-to-tail (HâT) dimers of 3-substituted thiophenes by the ...
Matti Knaapila , Rachel C. Evans , Vasil M. Garamus , László Almásy , Noémi K. Székely , Andrea Gutacker , Ullrich Scherf , and Hugh D. Burrows. Langmuir ...
Jun 2, 1971 - (2.43 M) with 6 (0.112 M; 45% cis, 55% trans), which was fol- lowed to 47% completion (230 min). Registry No.â3, 16327-48-3; 4a, 16327-50-7 ...
Achowledgment.-We are grateful to 3Ir. Sidney. Featherman for assistance in developing gas chroma- tographic conditions for 6 , and to Mr. Joseph J. Breen.
The characteristic constituent of the essential oil of citronella is an aldehyde, having the composition C10Hi8O, and known as citronellic aldehyde, or citronellal.
Derek Redmore. J. Org. Chem. , 1978, 43 (5), pp 992â .... King Abdullah University of Science and Technology (KAUST) Professor Peiying Hong is the recipient .
J. Med. Chem. 1991,34, 1998-2003
1998
material). Reminimization was then done in AMBER. The octanucleotide duplex d(GATGCAT02was constructed and minimized in AMBER using Amott's B DNA geometry.% Figure 3 shows a schematic for this sequence. Minimized saframycin A species were docked onto it near G4 using MIDAS. In many cases, it was obvious that certain orientations would give unsatisfactory models. For protonated saframycin A hydroquinone the covalent models were made in both the 3' and 5' direction. Subsequent models were made only in the 3' direction. Coordinates of the docked models were captured and the structures were refined in AMBER to a root mean square value of
