Synthesis of Some New N-o-Tolyl-X’-2-(substituted) Benzothiazolylguanidines
Certniu substituted diguaiiitles hare shoivii :intiinalarial activities’ which created interest in searching for other therapeutically useful members in this series md, in due course, led t o the discovery of high autitacterial activity,2 nioro commonly anlong a series of histliguanides. Biguaiiirlo d e r i r a t i v e ~of~ ,diary1 ~ sulfones ttnti. sulfides have been found to exhibit activity in citio against 31ycobwcterium tuberculosis. Recently, Bhargava, et have shown that hydrochlorides of several beiizothiazolglgua~~idines art mor(; ~
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(1) F. 11. S.Curd and .:1 L. Rose, J . C’hem. Soc., 726 (1946). (2) F. L. Rose and G. Swain, ibid., -1422 (1!?>6). ( 3 ) R. P;. Jayasimha, S. C . Rhnttncharya, and 1’. C. Guha, Current Sci. (India), 20, 158 (1951). (4) M. Sirsi, B. N. Jayasimha, and J . R. Iyengar, ibid., 20, 237 (1951). ( 5 ) P. N. Bhargava and K. 8. Devi, J . Indian Chem. Soc., 40, 868 (1963). (61 P. N. Bhargava and P. Rain, I n d i a n J . Chem., 4, 95 (1966).
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actirc against gram-positivc bacteria than against gram-negative oiitb. Some S-ni- (or p - ) tolyl-X’-2(substitutetl)teiizothiazolg~l-?;”-alliylguaiiidiiles liavc h c i i fouiitl activt. :Lgainst J I . tuberculosis ( H 3 7 R ~ ~ ) . i ~ 8 ( i j 1’. N. Ilhargara : i i i , l 13. J.:ikhan, .lyi.. Bioi. C h m i . (Tolilo), 32, l:j92 (I(l68). (8) 1’. K. Bhnrgiivn :ind 31. Ihis sort,. This would have led to some very desirable priming, and perhaps to the rejection of some of it. It remains to be iioted that the printing and lay-out are excellent.
AIEDICAL COLLEGEOF VIRGINIA HICHMOND, T’IRGIMA
IAN E. BUSH
The Structure and Function of Enzymes. By SIDXEYA. BERSHARD. W. A. Benjamin, Inc., Kew York, Amsterdam. 1968. 321 pp. 21 x 13.8 cm. Paperback, $4.95. Cloth, xi $10.00.
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Xeither the iindergiadiiate curriculiim in chemistry nor biology i n Americaii iuiiversities piovides enoiigh time or background
