New model systems for the measurement of weak non-covalent interactions Ken D. Shimizu, Department of Chemistry and Biochemistry, University of South Carolina, Columbia SC 29208 Goal: to measure and study weak non-covalent interactions such as hydrogen bonding and arene-arene interactions using molecular balances.
molecular balance O O N
O N
O Ph
O Ph O
O Ph
O
unfolded
Ph
folded
Non-covalent face-to-face arene-arene interaction
1.00 0.75
-ΔG 0.50 (kcal/mol)
[folded] ΔGarene-arene = -RT ln [unfolded]
0.25 0 benzene
phenanthrene
arene size
pyrene
