Jay K. Trautman will receive the first Arthur F. Findeis Award for Achievements by a Young Analytical Scientist, sponsored by The Philip Morris Companies. Trautman recently left Bell Labs to take a position as director of research at SEQ, a company devoted to developing a single-molecule DNA sequencer, and is involved in near-field scanning optical microscopy.
They coupled low-flow (< 1 nL/rnin) electrospray ionization with sheathless 5-um i.d. CE and, using a 6-T FT-MS, were able to obtain full spectra at unit resolution for 0.7-3 x 1CT18-mol injections of proteins with molecular masses ranging from 8 kDa to 29 kDa. Errors in the molecular weight were less than 1 Da. The eetection limits for ubiquitin and equine cytochrome c were 0.9 amol and 0.7 amol, respectively. They were also able to measure human carbonic anhydrase from cell lysate at a level of 8 ± ± amol.
20-T FT-ICRMS NEWS FROM ASMS
Biemann Medal established At the awards ceremony of the 44th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics in Portland, OR, in May, Ronald A. Hites, professor of chemistry and of environmental and public affairs at Indiana University-Bloomington, announced the establishment of the Klaus Biemann Medal to be awarded annually by ASMS. The award funded entirely by former students, postdoctoral associates, and friends of Biemann will recognize scientists who have made significant contributions to basic or applied MS early in their careers. The award is presented "in honor of Professor Klaus Biemann as an educator and scientist and in honor of his lasting legacy resulting from the training of students and postdoctoral associates over a 40-year period at the Massachusetts Institute of Technology" and will include the Biemann Medal a cash award and travel exoenses to
High magneticfieldsbring many advantages to FT-MS—increased mass resolving power, upper mass limit, number of ions, and ion lifetimes. The highest field superconducting magnet available for FTICR is 9.4 T. Alan G. Marshall and coworkers at the National High Magnetic Field Laboratory (NHMFL) at Florida State University have constructed an FTICRMS by using a 20-T resistive magnet with a 50-mm diameter bore and 1000ppm spatial homogeneity. Although resistive magnets have less spatial and temporal field homogeneity than superconducting magnets, Marshall's
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group has obtained MALDI/FT-ICR mass spectra of luteinizing-releasing hormone with a mass resolving power (m/Am) of ~ 10,000 and of the cluster Pt4(PF3)8 with a resolving power of ~ 20,000. They attribute their success, which defies the magnet's spatial inhomogeneities, to averaging from the ion cyclotron.
Have TOF, will travel Dave Chambers and Louis Grace of Lawrence Iivermore National Laboratory have developed a direct air sampling quadrupole ion storage/reflectrontime-of-flightmass spectrometer (QUISTOR/reTOF-MS) for air monitoring that can be transported on a cart 36.5-in long x 24-in wide x 15.25-in deep. Chambers says that to aid in the miniaturization they have designed the pumping system with "the fewest number of pumps we can get away with." The instrument has one turbomolecular pump, but the remainder of the instrument is baffled so that the pressure in the sampling region is higher than that of the reTOF-MS but lower than that of the atmosphere. Air is drawn continuously into the instrument. The analyte ions are held in the trap on the order of milliseconds, but the analysis takes only microseconds, which makes the duty cycle effectively 100%. Although the 4 s necessary to write the data to the disk of the oscilloscope limit the time of analysis, Chambers and Grace are designing a data system that will allow true real-time data storage. The instrument has a detection limit for VOCs of 10 ppb to 700 pptr rnd has sben used to measure Freon 11 at 3 ppb with a mass resolution of ~ 1600. Preliminary field tests indicate that it can detect changes from background air, which is the main purpose of the instrument, but Chambers and Grace have not determined if the changes are the result of a single compound or a mixture.
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Picospray ESI of proteins Mass spectrometrists continue to decrease the size of electrospray while increasing its sensitivity. Fred McLafferty's laboratory at Cornell University reported the characterization of proteins with attomole sensitivity by "picospray" CE/ESI tandem MS.
Jared Drader (left), Christopher Hendrickson (middle), and Marshall with the 20-T FT-ICRMS system at the NHMFL in Gainesville, FL. (Courtesy of the NHMFL.
The QUISTOR/reTOF-MS. (Courtesy of LLNL.)
Analytical Chemistry News & Features, July 1, 1996 4 0 5 A
