Editorial pubs.acs.org/ac
NMR Developments and Applications
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Notes
his virtual issue focuses on developments and applications in NMR spectroscopy and is a collaborative effort between two journals, Analytical Chemistry and The Journal of Physical Chemistry. This virtual issue consists of 14 papers published in Analytical Chemistry and 14 papers published in The Journal of Physical Chemistry B and C (JPC B; JPC C) since 2014. The papers have been selected as recent examples of innovative methods and interesting applications of solution and solid-state NMR spectroscopy. The goals of this special issue are to highlight advances in NMR spectroscopy and provide insight into how new methods can be deployed to address a number of important measurement challenges and study a range of materials and biological systems. The papers selected from The JPC B and C include studies of materials and biological systems, such as porous materials (zeolites, metal organic frameworks), ionic liquids, enzymes, membranes, amino acids, cellulose, and lithium battery materials. NMR experiments utilized in these studies include magic angle spinning, multiple quantum, diffusion, relaxation, and dynamic nuclear polarization (DNP). In addition, in many of the papers selected, computational methods and other experimental characterization techniques (such as X-ray diffraction, optical methods, and electrochemical methods) are used in combination with NMR spectroscopy. Several papers selected from Analytical Chemistry address improvements in methods for metabolomics and metabolic flux analysis or in vivo measurements. Others present methods for characterizing chemical reactions using a microfluidic system to determine kinetic parameters or in a unique approach to spectroelectrochemistry coupling ultrafast 2D NMR spectroscopy with an in situ electrochemical cell to detect unstable redox intermediates. Other studies take advantage of recent advances that impact NMR sensitivity to increase polarization through DNP or para-hydrogen. Creative applications of quantitative NMR range from the characterization of functionalized nanoparticles and materials, to monitoring the blood clearance of PEGylated biomacromolecules in live rats. NMR is unique as a tool for analytical and physical chemistry measurements providing exquisite molecular-level structural and dynamic information. Investigators continue to push the limits of NMR selectivity and sensitivity by applying NMR to creatively address frontiers in chemistry, biology, and materials science.
Views expressed in this editorial are those of the authors and not necessarily the views of the ACS.
Cindy K. Larive, Associate Editor Analytical Chemistry University of California, Riverside
Sarah C. Larsen, Senior Editor The Journal of Physical Chemistry
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University of Iowa
AUTHOR INFORMATION
ORCID
Sarah C. Larsen: 0000-0002-9736-4964 © XXXX American Chemical Society
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DOI: 10.1021/acs.analchem.6b05082 Anal. Chem. XXXX, XXX, XXX−XXX
