Occurrence of Halogenated Transformation Products of Selected

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Occurrence of Halogenated Transformation Products of Selected Pharmaceuticals and Personal Care Products in Secondary and Tertiary Treated Wastewaters from Southern California Daryl N. Bulloch,† Eric D. Nelson,*,‡ Steve A. Carr,‡ Chris R. Wissman,‡ Jeffrey L. Armstrong,§ Daniel Schlenk,∥ and Cynthia K. Larive*,† †

Department of Chemistry, University of CaliforniaRiverside, Riverside, California 92521, United States San Jose Creek Water Quality Laboratory, Sanitation Districts of Los Angeles County, 1965 Workman Mill Road, Whittier, California 90601, United States § Environmental Laboratory and Ocean Monitoring Division, Orange County Sanitation District, 10844 Ellis Avenue, Fountain Valley, California 92708, United States ∥ Department of Environmental Sciences, University of CaliforniaRiverside, Riverside, California 92521,United States ‡

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ABSTRACT: Final effluent samples from 10 southern California (United States) wastewater treatment facilities, employing four distinct treatment schemes, were surveyed for selected pharmaceuticals, personal care products (PPCPs), alkylphenols, and 21 of their halogenated disinfection byproducts. Chlorinated and brominated standards and isotopically labeled internal standards were synthesized and purified to confirm and more accurately quantify selected disinfection byproducts of salicylic acid, bisphenol A, gemfibrozil, naproxen, diclofenac, technical 4-nonylphenol, and 4-tert-octylphenol using high-performance liquid chromatography and tandem mass spectrometry. Concentrations of parent compounds ranged from