Accepted: 30 May 2017 DOI: 10.1111/jocd.12369
ORIGINAL CONTRIBUTION
In vitro evaluation of chitosan-coated liposome containing both coenzyme Q10 and alpha-lipoic acid: Cytotoxicity, antioxidant activity, and antimicrobial activity Guodong Zhao MS2
| Caibiao Hu PhD3 | Ying Xue MS1
1 Center for Reproduction and Genetics, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu, China
Summary Background: Chitosan-coated liposome containing both coenzyme Q10 and alpha-
2
Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, Jiangsu, China 3
State Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing, Jiangsu, China Correspondence Ying Xue, Center for Reproduction and Genetics, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou, Jiangsu, China. Email:
[email protected] Funding information “Hundred Talents Program” of Chinese Academy of Sciences, Grant/Award Number: Y421021102, Y521051102; Key Technologies R & D Program for Social Development of Jiangsu Province, Grant/ Award Number: BE2016685; Suzhou Leading Talent Project, Grant/Award Number: ZXL2014128; New Medical Devices and Pharmaceuticals Fund of Suzhou, Grant/Award Number: ZXY201430; Hundred Talents Program of Chinese Academy of Sciences
lipoic acid (CCAL) was a novel multifunctional nano delivery system exhibited longterm stability at room temperature and high encapsulation efficiency. Which containing two kinds of antioxidants (coenzyme Q10 and alpha-lipoic acid) and two antibacterial agents (chitosan and alpha-lipoic acid). However, the further biocompatibility, such as cytotoxicity and antioxidant activity, and antimicrobial activity of CCAL, has not been systematically evaluated. Objectives: This study aims to evaluate the cytotoxicity, antioxidant activity and antimicrobial activity of CCAL. Methods: This article evaluated the in vitro cytotoxicity and antioxidant activity of CCAL by CCK8 assay, and antimicrobial activity on Staphylococcus aureus and Escherichia coli was investigated. Results: For antioxidant activity study, CCAL displayed significant antioxidant effect when compared with control group (P
